ASSOCIATIONS OF HIGH-DENSITY-LIPOPROTEIN SUBCLASSES AND APOLIPOPROTEINS WITH ISCHEMIC-HEART-DISEASE AND CORONARY ATHEROSCLEROSIS
ASSOCIATIONS OF HIGH-DENSITY-LIPOPROTEIN SUBCLASSES AND APOLIPOPROTEINS WITH ISCHEMIC-HEART-DISEASE AND CORONARY ATHEROSCLEROSIS
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DOI：
10.1016/0002-8703(87)90638-7
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发表时间：
1987-02-01
影响因子：
4.8
通讯作者：
MILLER, NE
中科院分区：
文献类型：
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作者：
MILLER, NE
一些国家的前瞻性研究表明，缺血性心脏病（IHD）的发病率与高密度脂蛋白（HDL）胆固醇浓度呈负相关。1~ 2现在已经确定HDL颗粒在大小、密度、漂浮率以及脂质和载脂蛋白组成3方面表现出相当大的异质性，并且整个家族的胆固醇含量是几个亚类的组成和颗粒数量的复杂函数。因为每一种都在HDL代谢中占据不同的位置，所以有些可能与IHD的关系比其他更强。比较不同亚类与疾病的相关性的相对强度有两个原因。首先，如果测量方法适合常规使用，那么识别出比高密度脂蛋白胆固醇更强大的亚类作为风险因素将具有相当大的临床实用性。其次，这些研究的结果可能会提供深入了解HDL和IHD.As测量亚类之间的联系的分子基础，一些研究人员已经探索了HDL载脂蛋白与疾病的关联。这种方法具有与子类分析相同的潜在好处，并且在技术上要求更低。因为主要的HDL载脂蛋白AI和AI 1几乎完全局限于HDL，所以它们可以在整个血浆中定量。由于脂蛋白的代谢在很大程度上取决于其载脂蛋白的含量，因此也可以从理论上对载脂蛋白进行测量。
Prospective studies in several countries have demonstrated an inverse association between incidence of ischemic heart disease (IHD) and high-density lipoprotein (HDL) cholesterol concentration. 1~ 2 It is now established that HDL particles exhibit considerable heterogeneity of size, density, and flotation rate, and of lipid and apoprotein composition3 and that the cholesterol content of the entire family is a complex function of the compositions and particle numbers of several subclasses. Because each of these occupies a different place in HDL metabolism, it is possible that some will have a stronger relationship to IHD than others. Comparisons of the relative strengths of the associations of different subclasses with disease are of interest for two reasons. First, the identification of a subclass that is more powerful than HDL cholesterol as a risk factor would have considerable clinical utility if the method of measurement were suitable for routine use. Second, the results of such studies might provide insight into the molecular basis of the link between HDL and IHD.As an alternative to measuring subclasses, some investigators have explored the associations of HDL apoproteins with disease. This approach has the same potential benefits as subclass analysis, with the added attraction of being technically less demanding. Because the major HDL apoproteins AI and AI1 are confined almost entirely to HDL, they can be quantified in whole plasma. A case for measurement of apoproteins can also be made on theoretical grounds, since the metabolism of lipoproteins is largely determined by their apoprotein content.