Effects of Halothane, Pentobarbital and Ketamine on Serum Melatonin Levels in the Early Scotophase in New Zealand White Rabbits
Effects of Halothane, Pentobarbital and Ketamine on Serum Melatonin Levels in the Early Scotophase in New Zealand White Rabbits
复制标题
氟烷、戊巴比妥和氯胺酮对新西兰白兔早昏期血清褪黑素水平的影响
作者：
C. S. Pang;C. Mulnier;S. Pang;Joseph C.S. Yang
在哺乳动物中，夜间松果体褪黑素的上升是由内源性时钟（下丘脑视交叉上核）的信号调节的。关于麻醉药调节多突触神经元功能是否影响褪黑激素分泌的报道很少。我们研究了氟烷、戊巴比妥和氯胺酮三种常用麻醉剂对雄性新西兰大白兔血清褪黑素水平的影响。在麻醉前、麻醉中和麻醉后，每隔30-60分钟采集7份血样。实验在光照后期和暗前期进行，因此褪黑激素分泌的变化将反映在夜间血清褪黑激素的发作和/或水平上。用放射免疫法测定血清褪黑素水平。结果表明，氟烷能减弱褪黑激素的释放，戊巴比妥对褪黑激素的释放无明显影响，而氯胺酮能增强褪黑激素的释放。这些发现表明，在氟烷或氯胺酮麻醉的患者中，褪黑激素水平可能受到影响，导致生物节律紊乱，尤其是恢复后的睡眠-觉醒周期。
In mammals, the nocturnal rise in pineal melatonin is regulated by signals from the endogenous clock, the hypothalamic suprachiasmatic nuclei. There have been few reports on whether anaesthetics which modulate multisynaptic neuronal functions affect melatonin secretion. We studied the effects of three commonly used anaesthetics, halothane, pentobarbital and ketamine, on serum melatonin levels in male New Zealand white rabbits. Seven blood samples were collected, 30–60 min apart, before, during and after anaesthesia. Experiments were performed in the late light and early dark period, so that changes in melatonin secretion would be reflected in the onset and/or level of nocturnal serum melatonin. Serum melatonin levels were determined by radioimmunoassay. Our results indicated that halothane attenuated the release of melatonin and pentobarbital had no apparent effect, whereas ketamine potentiated the release of melatonin. These findings suggest that melatonin levels may be affected in patients anaesthetized with halothane or ketamine, resulting in disturbed biological rhythms, especially the sleep-wake cycle following recovery.
仓鼠视交叉上核的体内代谢活动：使用麻醉。
DOI：
10.1152/ajpregu.1987.252.2.r419
发表时间：
1987
期刊：
The American journal of physiology
影响因子：
--
作者：
Schwartz,WJ
通讯作者：
Schwartz,WJ
通过定量 F2-异前列腺素证明氟烷诱导的大鼠肝脂质过氧化。
影响因子：
8.8
作者：
Awad,JA;Horn,JL;Roberts2nd,LJ;Franks,JJ
通讯作者：
Franks,JJ