INDIUM-111-GRANULOCYTE SCANNING IN THE ASSESSMENT OF DISEASE EXTENT AND DISEASE-ACTIVITY IN INFLAMMATORY BOWEL-DISEASE - A COMPARISON WITH COLONOSCOPY, HISTOLOGY, AND FECAL INDIUM-111-GRANULOCYTE EXCRETION
INDIUM-111-GRANULOCYTE SCANNING IN THE ASSESSMENT OF DISEASE EXTENT AND DISEASE-ACTIVITY IN INFLAMMATORY BOWEL-DISEASE - A COMPARISON WITH COLONOSCOPY, HISTOLOGY, AND FECAL INDIUM-111-GRANULOCYTE EXCRETION
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DOI：
10.1016/0016-5085(86)90376-8
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发表时间：
1986-05-01
期刊：
影响因子：
29.4
通讯作者：
CHADWICK, VS
中科院分区：
文献类型：
--
作者：
SAVERYMUTTU, SH;CAMILLERI, M;CHADWICK, VS
铟111-白细胞扫描作为炎症性肠病的一种新的成像方法最近被引入。最近，通过标记纯粒细胞部分而不是传统的混合白细胞制剂，这项技术对急性炎症更具特异性。我们现在报道一项前瞻性研究，将111In-粒细胞扫描与内窥镜、组织学和粪便111In-粒细胞排泄物进行比较，以评估结肠炎性肠病的疾病范围和严重程度。对52例克罗恩‘’S病或溃疡性结肠炎患者进行了大体、组织学或数值分级系统的检查，发现胃镜和组织学检查与111In检查有很好的相关性[r=0.90(肠镜检查)和r=0.90(组织学检查)；r=0.86和r=0.91(疾病活动性)]。扫描分级的严重程度也与粪便111粒细胞排泄密切相关(r=0.9)。铟111颗粒细胞扫描是一种快速、准确、无创的评估炎症性肠病病变程度和结肠受累程度的方法。
Indium 111-leukocyte scanning has recently been introduced as a new method for imaging inflammatory bowel disease. The technique has recently been made more specific for acute inflammation by labeling a pure granulocyte fraction rather than the conventional mixed leukocyte preparation. We now report a prospective study comparing 111In-granulocyte scanning with endoscopy, histology, and fecal 111In-granulocyte excretion for the assessment of disease extent and severity in colonic inflammatory bowel disease. In 52 patients with Crohn''s disease or ulcerative colitis, disease extent and severity were assessed macroscopically, histologically, or by scanning using a numerical grading system. Excellent correlations were found between both endoscopy and histology and 111In scans [r=0.90 (endoscopy) and r=0.90 (histology) for extent; r=0.86 and r=0.91 for disease activity]. Severity graded by scanning also showed a close correlation with fecal 111In-granulocyte excretion (r=0.90). Indium 111-granulocyte scans are a rapid, accurate, noninvasive means of assessing both disease extent and severity of colonic involvement in inflammatory bowel disease.