Rheological and cohesive properties of hyaluronic acid
Rheological and cohesive properties of hyaluronic acid
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DOI：
10.1002/jbm.a.30623
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发表时间：
2006-03-15
影响因子：
4.9
通讯作者：
Berg, RA
中科院分区：
文献类型：
--
作者：
Falcone, SJ;Palmeri, DM;Berg, RA
透明质酸（HA）是一种天然存在的多糖，具有独特的生物医学用途。我们研究了三种分子量(0.35 X 10（6) -1.80 X 10(6) Da）的HA的粘结性和流变性能，发现HA的粘结性高度依赖于分子量和溶液浓度。近似地说，溶液中透明质酸的内聚性与浓度有关，而与分子量无关。几个与分子量相关的流变参数：零剪切粘度、复粘度和交点处的复粘度。通过动态吸入测量HA溶液的内聚性（Poyer等，J Cataract Refract surgery 1.998;24:1130-1135），发现随着零剪切粘度的增加，HA溶液的内聚性降低。研究发现，HA聚合物在溶液中的黏合性能与高频络合粘度和高频损失模量有关，而与分子量无关。(c) 2005 Wiley期刊有限公司
Hyaluronic acid (HA) is a naturally occurring polysaccharide With unique biomedical applications. We have Studied the cohesive and rheological properties of HA of three molecular weights (0.35 X 10(6) -1.80 X 10(6) Da) and found that the cohesive nature of HA was highly dependent on molecular weight and solution concentration. To a first approximation, the cohesive nature of HA in solution correlates with concentration, independent of molecular weight. Several rheological parameters correlated with molecular weight: zero shear viscosity, complex viscosity, and the complex viscosity at the crossover point. The cohesive properties of the HA solutions, measured by dynamic aspiration (Poyer et al, J Cataract Refract surg 1.998;24:1130-1135), were found to decrease as the zero shear viscosity increases. The cohesive properties of HA polymer in solution were found to correlate with the high frequency complex viscosity and high frequency loss modulus independent of molecular weight. (c) 2005 Wiley Periodicals, Inc.