In-vitro photothermal therapy using plant extract polyphenols functionalized graphene sheets for treatment of lung cancer
In-vitro photothermal therapy using plant extract polyphenols functionalized graphene sheets for treatment of lung cancer
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DOI：
10.1016/j.jphotobiol.2019.111587
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发表时间：
2020-03-01
影响因子：
5.4
通讯作者：
Fang, Zheng
中科院分区：
文献类型：
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作者：
Wang, Chunmei;Wang, Xiangyun;Fang, Zheng
尽管近年来光热疗法（PTT）取得了巨大的进步，但要实现肿瘤细胞的高效靶向光热去除，还需进一步完善。由于这一要求，我们展示了一类新型的还原氧化石墨烯基光热治疗剂，用于肺癌细胞的消融（A549）。利用Memecylon dule叶提取物介导氧化石墨烯（GO）的还原，一步制备石墨烯纳米片。该过程不包括使用任何有毒或有害的还原剂。通过排除氧化石墨烯中含氧基团和连续稳定生成的氧化石墨烯，对氧化石墨烯和棉兰叶提取物的不同表征的相对结果提供了一种潜在的表征。氧化多酚与氧化氧化石墨烯的官能化降低了它们的稳定性，从而避免了聚集。在体外实验中，多酚锚定的还原氧化石墨烯（RGO）在肺癌细胞的近红外（NIR）照射下表现出异常的细胞毒性。在癌症治疗方面取得有限成功的领域，我们的翻译结果可以为设计靶向PTT药物提供途径，并对刺激环境做出反应，以安全消融破坏性疾病。
Although the photothermal therapy (PTT) has achieved tremendous progress in the recent times, still it has to improve an extensive way to achieve the efficient targeted photothermal removal of the tumor cells. Owing to this requirement, we demonstrated a novel class of reduced graphene oxide based photothermal therapeutic agent for the ablation of lung cancer cells (A549). A single step bio facile fabrication of graphene nanosheets using Memecylon edule leaf extract intermediated reduction of Graphene Oxide (GO). This process does not include the utilization of any toxic or harmful reducing agents. The relative results of different characterizations of graphene oxide and Memecylon edule leaf extract RGO delivers a potential representation by excluding the groups containing oxygen from GO and consecutive stabilization of the developed RGO. The reduced GO functionalization with the oxidized polyphenols results in their stability by avoiding the aggregation. The poly phenol anchored Reduced Graphene Oxide (RGO) exhibited exceptional near-infrared (NIR) irradiation of the lung cancer cells directed in vitro to deliver cytotoxicity. In an area of restricted success in the treatment of cancer, the results of our translation can provide a path for designing targeted PTT agents and also responds to stimulus environment for the safe ablation of the devastating disease.