Transfer RNA modifications and modifying enzymes in Saccharomyces cerevisiae
Transfer RNA modifications and modifying enzymes in Saccharomyces cerevisiae
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DOI：
10.1007/b105814
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发表时间：
2005-01-01
期刊：
影响因子：
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通讯作者：
Byström, AS
中科院分区：
文献类型：
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作者：
Johansson, MJO;Byström, AS
AbstractTransfer RNAs are adaptor molecules, which decode mRNA into protein and, thereby, play a central role in gene expression. During the maturation of a primary tRNA transcript, specific subsets of the four normal nucleosides adenosine, cytidine, guanosine, and uridine are modified. The formation of a modified nucleoside can require more than one gene product and may involve several enzymatic steps. In the last few years, the identification of gene products required for formation of modified nucleosides in tRNA has dramatically increased. In this review, proteins involved in modification of cytoplasmic tRNAs inSaccharomyces cerevisiaeare described, emphasizing phenotypic characteristics of modification deficient strains and genetic approaches used to determine the in vivo role of modified nucleosides/modifying enzymes.
