Nanoscale engineering of a cellular interface with semiconductor nanoparticle films for photoelectric stimulation of neurons
Nanoscale engineering of a cellular interface with semiconductor nanoparticle films for photoelectric stimulation of neurons
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DOI：
10.1021/nl062513v
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发表时间：
2007-02-01
期刊：
影响因子：
10.8
通讯作者：
Kotov, Nicholas A.
中科院分区：
文献类型：
--
作者：
Pappas, Todd C.;Wickramanyake, W. M. Shan;Kotov, Nicholas A.
纳米结构材料卓越的光学和电学特性现在被认为是各种生物材料、生物传感和细胞界面应用的来源。在这项研究中，我们报告了混合生物纳米器件的第一个例子，其中由层层组装产生的量子限制的HgTe半导体纳米颗粒薄膜通过一系列光化学和电荷转移反应刺激附着的神经细胞吸收光。我们还展示了一个由生物功能驱动的纳米级工程材料的例子。
The remarkable optical and electrical properties of nanostructured materials are considered now as a source for a variety of biomaterials, biosensing, and cell interface applications. In this study, we report the first example of hybrid bionanodevice where absorption of light by thin films of quantum confined semiconductor nanoparticles of HgTe produced by the layer-by-layer assembly stimulate adherent neural cells via a sequence of photochemical and charge-transfer reactions. We also demonstrate an example of nanoscale engineering of the material driven by biological functionalities.