Signal integration between IFNγ and TLR signalling pathways in macrophages
Signal integration between IFNγ and TLR signalling pathways in macrophages
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DOI：
10.1016/j.imbio.2006.05.007
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发表时间：
2006-01-01
期刊：
影响因子：
2.8
通讯作者：
Hume, David A.
中科院分区：
文献类型：
--
作者：
Schroder, Kate;Sweet, Matthew J.;Hume, David A.
巨噬细胞是先天免疫系统的主要效应细胞，并且巨噬细胞功能的适当调节需要整合来源于宿主因子（例如干扰素-γ/IFN γ）和病原体产物（例如toll样受体/TLR激动剂）的识别的多种信号传导输入。IFN γ预处理（“引发”）对TLR诱导的巨噬细胞活化的深远影响早已被认识，但引发表型的许多机制只是最近才被确定。这篇综述总结了已知的IFN γ和TLR信号通路之间的整合机制。协同作用发生在多个水平，从信号识别到信号在靶基因启动子处的会聚。特别是，干扰素γ和LPS和CpG DNA信号通路之间的串扰进行了讨论。(c)2006年Elsevier GmbH。All rights reserved.
Macrophages are major effector cells of the innate immune system, and appropriate regulation of macrophage function requires the integration of multiple signalling inputs derived from the recognition of host factors (e.g. interferon-gamma/IFN gamma) and pathogen products (e.g. toll-like receptor/TLR agonists). The profound effects of IFN gamma pre-treatment ("priming") on TLR-induced macrophage activation have long been recognised, but many of the mechanisms underlying the priming phenotype have only recently been identified. This review summarises the known mechanisms of integration between the IFN gamma and TLR signalling pathways. Synergy occurs at multiple levels, ranging from signal recognition to convergence of signals at the promoters of target genes. In particular, the cross-talk between the IFN gamma and LPS and CpG DNA signalling pathways is discussed. (c) 2006 Elsevier GmbH. All rights reserved.