Inhibitors of nitric oxide synthase selectively reduce flow in tumour‐associated neovasculature
Inhibitors of nitric oxide synthase selectively reduce flow in tumour‐associated neovasculature
复制标题
一氧化氮合酶抑制剂选择性减少肿瘤相关新血管系统中的血流
DOI：
--
复制
发表时间：
1992
影响因子：
7.3
通讯作者：
P. Piper
中科院分区：
文献类型：
--
作者：
S. P. Andrade;I. Hart;P. Piper
1研究了L-精氨酸类似物、N-硝基-L-精氨酸甲酯(L-NAME)、N-单甲基-L-精氨酸(N-甲基-L-精氨酸)和亚甲蓝对小鼠腺癌和黑色素瘤血流的影响。2用Balb/c和C57/BL小鼠体内的海绵植入肿瘤细胞，用~(133)Xe洗脱法检测移植海绵的局部血流。3药物抑制一氧化氮(NO)可减少两种肿瘤的血流量，但这种作用可被L-精氨酸逆转。4与此形成鲜明对比的是，这些NO抑制剂对海绵诱导的非肿瘤性肉芽组织血流的影响微乎其微。5这些结果强烈表明：(A)肿瘤血管中的流动受到维持肿瘤组织扩张器张力的一氧化氮的调节；(B)NO抑制剂的收缩活动(通过增加133Xe来监测)可能归因于这种扩张器张力的去除；(C)肿瘤血管系统中描述的许多异常，如对血管活性介质的低反应或无反应以及最大血管扩张，可能是由于癌症中NO合成增加所致。
1 The effects of l‐arginine analogues, NG‐nitro‐l‐arginine methyl ester (l‐NAME) and NG‐monomethyl‐l‐arginine (l‐NMMA) and methylene blue on blood flow in a murine adenocarcinoma and melanoma have been investigated. 2 Sponge implants in Balb/c and C57/BL mice were used to host proliferating tumour cells while the washout of 133Xe was employed to assess local blood flow in the implanted sponges. 3 Pharmacological inhibition of nitric oxide (NO) reduced blood flow in both tumours but this effect was reversed by administration of l‐arginine. 4 In marked contrast, the effect of these same NO inhibitors on the blood flow in sponge‐induced non‐neoplastic granulation tissue was negligible. 5 These results strongly suggest that: (a) flow in tumour vessels is modulated by nitric oxide which maintains a dilator tone in neoplastic tissue; (b) the constrictor activity (as monitored by an increase in t½ of 133Xe) of NO inhibitors may be attributed to the removal of such dilator tone; (c) many of the abnormalities described in tumour vasculature, such as hyporeactivity or unresponsiveness to vasoactive mediators and maximum vasodilatation, may be due to an increase in NO synthesis in cancers.
DOI：
--
发表时间：
1985-03
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
W. Martin;G. Villani;D. Jothianandan;R. Furchgott
通讯作者：
W. Martin;G. Villani;D. Jothianandan;R. Furchgott
DOI：
10.1073/pnas.82.22.7738
发表时间：
1985-01-01
影响因子：
11.1
作者：
STUEHR, DJ;MARLETTA, MA
通讯作者：
MARLETTA, MA