PROTECTIVE EFFECT OF NATURALLY ACQUIRED HOMOTYPIC AND HETEROTYPIC ROTAVIRUS ANTIBODIES
PROTECTIVE EFFECT OF NATURALLY ACQUIRED HOMOTYPIC AND HETEROTYPIC ROTAVIRUS ANTIBODIES
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天然获得的同型和异型轮状病毒抗体的保护作用
DOI：
10.1016/s0140-6736(86)92133-1
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
T. Nakao
中科院分区：
文献类型：
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作者：
S. Chiba;S. Nakata;T. Urasawa;S. Urasawa;Takashi Yokoyama;Yasuyuki Morita;K. Taniguchi;T. Nakao
为了评估轮状病毒胃肠炎免疫抵抗的血清型特异性，研究了针对同型和异型轮状病毒的现有中和抗体与针对感染或临床疾病的保护之间的关系。研究对象是札幌一家孤儿院的 44 名孤儿，他们连续接触过 3 型轮状病毒引起的胃肠炎一次或两次。在这些暴发期间收集了血清，并在暴发前后测量了针对 A 组人轮状病毒四种不同血清型的中和抗体的血清水平。对轮状病毒胃肠炎的保护似乎具有血清型特异性，并且与抗同型病毒的抗体水平有关。 1/128 或更高的中和抗体水平似乎具有保护作用。保护作用持续时间短，这可能是由沙恩血清型轮状病毒引起的胃肠炎反复发作的原因。大多数感染 3 型轮状病毒的儿童出现针对 1 型或 4 型轮状病毒的血清转化或伴随抗体反应，表明轮状病毒疫苗可以诱导对异型病毒的免疫力。
To assess serotype specificity of immune resistance to rotavirus gastroenteritis, the relation between pre-existing neutralising antibodies to homotypic and heterotypic rotaviruses and protection against infection or clinical illness was investigated. The subjects were 44 orphans exposed once or twice to consecutive outbreaks of gastroenteritis due to type 3 rotavirus in an orphanage in Sapporo. Sera were collected throughout these outbreaks and the serum levels of neutralising antibodies against four different serotypes of group A human rotavirus were measured before and after the outbreaks. Protection against rotavirus gastroenteritis seemed to be serotype specific and to be related to levels of antibody against homotypic virus. A neutralising antibody level of 1/128 or greater seemed to be protective. The protective effect was of short duration, which was probably the explanation for recurrent attacks of gastroenteritis due to a rotavirus of the sarne serotype. Seroconversions or concomitant antibody responses to type 1 or 4 rotavirus in most children with type 3 rotavirus infection suggested that immunity to heterotypic virus can be induced by a rotavirus vaccine.