Dcf1 regulates neuropeptide expression and maintains energy balance
Dcf1 regulates neuropeptide expression and maintains energy balance
复制标题
DCf1 调节神经肽表达并维持能量平衡
DOI：
10.1016/j.neulet.2017.03.052
复制
发表时间：
2017-05-22
影响因子：
2.5
通讯作者：
Wen, Tieqiao
中科院分区：
文献类型：
--
作者：
Liu, Qiang;Chen, Yu;Wen, Tieqiao
神经肽Y(NPY)是大脑中一种重要的神经递质，在食物摄取和能量储存中起着关键作用。虽然许多研究都集中在这些功能上，但NPY的表达调控仍不清楚。在这里，我们发现树突状细胞因子1(Dcf1)调节NPY的表达并维持能量平衡。我们发现Dcf1基因敲除(Dcf1(-/-)，KO)小鼠下丘脑NPY的表达显著减少。相反，Dcf1的过表达显著增加了细胞系中NPY的表达。我们还发现，Dcf1作用于NPY基因的上游，调节NPY的表达，并调节NPY-NPY受体1-GABA信号。值得注意的是，我们观察到Dcf1(-/-)小鼠的ATP浓度显著增加，这表明在缺乏Dcf1的情况下，对能量的需求更大。我们研究了Dcf1和NPY的关系，发现Dcf1在能量平衡中起着关键作用。(C)2017爱思唯尔B.V.保留所有权利。
Neuropeptide Y (NPY) is an important neurotransmitter in the brain that plays a pivotal role in food intake and energy storage. Although many studies have focused on these functions, the regulation of NPY expression remains unclear. Here we showed that dendritic cell factor 1 (Dcf1) regulates NPY expression and maintains energy balance. We found that NPY expression is significantly reduced in the hypothalamus of Dcf1 knockout (Dcf1(-/-), KO) mice. In contrast, Dcf1 overexpression significantly increases NPY expression in the cell line. We also found that Dcf1 acts upstream of the NPY gene to regulate NPY expression and modulates the NPY-NPY receptor 1-GABA signal. Notably, we observed a significant increase in the ATP concentration in Dcf1(-/-) mice, suggesting a greater demand for energy in the absence of Dcf1. We studied the relationship between Dcf1 and NPY and revealed that Dcf1 plays a critical role in energy balance. (C) 2017 Elsevier B.V. All rights reserved.