Calcium phosphopeptides -- mechanisms of action and evidence for clinical efficacy.
Calcium phosphopeptides -- mechanisms of action and evidence for clinical efficacy.
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DOI：
10.1177/0022034512454294
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发表时间：
2012-09-01
影响因子：
--
通讯作者：
Reynolds, E C
中科院分区：
文献类型：
--
作者：
Cochrane, N J;Reynolds, E C
具有酸性残基簇的磷酸蛋白/磷酸肽在整个自然界中被发现，它们有助于防止固体磷酸钙的不必要的沉淀。酸性残基，特别是磷酸丝氨酸，与钙相互作用并稳定钙和磷酸盐的簇。唾液和牛奶是含有这种磷蛋白/磷酸肽稳定的磷酸钙的生物液体的两个例子，并且两者共享相似的进化途径。唾液已被证明具有再矿化潜力，并且在维持口腔环境中牙齿的矿物质含量方面至关重要。牛奶可以被酶促改性以释放酪蛋白磷酸肽，酪蛋白磷酸肽含有允许牛奶稳定高浓度的钙和磷酸盐的残基簇。这些酪蛋白磷酸肽稳定的无定形磷酸钙纳米复合物（CPP-ACP）可以稳定甚至比牛奶更高浓度的钙和磷酸盐，并且可以被认为是唾液仿生物，因为它们与斯达林有许多相似之处。行动的机制和越来越多的科学证据，支持使用CPP-ACP，以增加氟抑制脱矿和提高矿化的白斑病变的审查。
Phosphoproteins/phosphopeptides with clusters of acidic residues are found throughout nature, where they aid in the prevention of unwanted precipitation of solid calcium phosphates. The acidic residues, particularly phosphoserine, interact with calcium and stabilize clusters of calcium and phosphate. Saliva and milk are two examples of biological fluids that contain such phosphoprotein/phosphopeptide-stabilized calcium phosphates, and both share a similar evolutionary pathway. Saliva has been shown to have remineralization potential and is of critical importance in maintaining the mineral content of teeth in the oral environment. Milk can be enzymatically modified to release casein phosphopeptides that contain the clusters of residues that allow milk to stabilize high concentrations of calcium and phosphate. These casein phosphopeptide-stabilized amorphous calcium phosphate nanocomplexes (CPP-ACP) can stabilize even higher concentrations of calcium and phosphate than milk and can be considered a salivary biomimetic, since they share many similarities to statherin. The mechanisms of action and the growing body of scientific evidence that supports the use of CPP-ACP to augment fluoride in inhibiting demineralization and enhancing the remineralization of white-spot lesions are reviewed.