Specific enrichment combined with highly efficient solid-phase tagging for the sensitive detection of heparin based on boronic acid-functionalized mesoporous silica nanospheres

Specific enrichment combined with highly efficient solid-phase tagging for the sensitive detection of heparin based on boronic acid-functionalized mesoporous silica nanospheres
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基于硼酸功能化介孔二氧化硅纳米球的特异性富集结合高效固相标记用于肝素的灵敏检测

DOI:
10.1039/c6cc06128a
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发表时间:
2016-01-01
影响因子:
4.9
通讯作者:
Cui, Xiao Bing
Cui, Xiao Bing
中科院分区:
化学2区
文献类型:
--
作者:
Zhu, Dong;Ye, Jing;Cui, Xiao Bing

文献摘要

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A combined specific enrichment and highly efficient solid-phase tagging approach is presented for heparin detection using boronic acid-functionalized mesoporous silica nanospheres as extraction sorbents and nanoscale reactors. It exhibits a faster reaction time (only 6 min), higher tagging-product purity and lower applicable sample concentration compared with liquid-phase tagging.