Anti-inflammatory, antiapoptotic, and antioxidant activity of fluoxetine.
Anti-inflammatory, antiapoptotic, and antioxidant activity of fluoxetine.
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DOI：
10.1002/prp2.231
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发表时间：
2016-06
影响因子：
2.6
通讯作者：
Evêncio Neto J
中科院分区：
文献类型：
--
作者：
Caiaffo V;Oliveira BD;de Sá FB;Evêncio Neto J
氟西汀是一种选择性的5-羟色胺摄取抑制剂，已被广泛用于测定5-羟色胺在中枢神经系统的神经传递。这种物质已经成为治疗抑郁症的首选药物，因为它更安全，副作用更少，耐受性更强。研究发现，氟西汀具有下列与中枢神经系统有关的重要功能：神经保护；类似于治疗炎症条件的标准药物的抗炎特性；抗氧化性，有助于其治疗作用，以及在临床实践中用于治疗不同应激相关不良健康状况的重要药理作用的重要细胞内机制；以及抗凋亡特性，具有更大的神经元存活率，减少细胞凋亡介质以及氧化物质，如超氧化物歧化酶和过氧化氢。本研究的目的是对氟西汀在抗炎、细胞存活和神经元营养机制(抗凋亡特性)中的重要作用以及它在抗氧化防御系统中的酶的作用的文献进行综述。
Fluoxetine is a selective serotonin uptake inhibitor that has been widely used to determine the neurotransmission of serotonin in the central nervous system. This substance has emerged as the drug of choice for the treatment of depression due to is safer profile, fewer side effects, and greater tolerability. Studies have found the following important functions of fluoxetine related to the central nervous system: neuroprotection; anti‐inflammatory properties similar to standard drugs for the treatment of inflammatory conditions; antioxidant properties, contributing to its therapeutic action and an important intracellular mechanism underlying the protective pharmacological effects seen in clinical practice in the treatment of different stress‐related adverse health conditions; and antiapoptotic properties, with greater neuron survival and a reduction in apoptosis mediators as well as oxidative substances, such as superoxide dismutase and hydrogen peroxide. The aim of this study was to perform a review of the literature on the important role of fluoxetine in anti‐inflammatory, cell survival, and neuron trophicity mechanisms (antiapoptotic properties) as well as its role regarding enzymes of the antioxidant defense system.