Increased exhaled carbon monoxide concentration during living donor liver transplantation.
Increased exhaled carbon monoxide concentration during living donor liver transplantation.
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活体肝移植期间呼出的一氧化碳浓度增加。
DOI：
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发表时间：
2008
影响因子：
5.4
通讯作者：
K. Morita
中科院分区：
文献类型：
--
作者：
T. Matsusaki;H. Morimatsu;Toru Takahashi;M. Matsumi;Kenji Sato;R. Kaku;Tetsufumi Sato;T. Yagi;N. Tanaka;K. Morita
据报道，呼出一氧化碳浓度 (ExCO-C) 会增加氧化组织损伤（例如全身炎症），并被认为反映了受影响器官中血红素分解的增加。当移植的肝脏经历缺血再灌注时，我们假设 ExCO-C 也可能在肝移植后增加，并可能作为移植组织损伤严重程度的衡量标准。我们连续前瞻性地研究了 67 名活体肝移植 (LDLT) 患者。麻醉期间，在 6 个时间点测定 ExCO-C，从麻醉诱导到进入重症监护室。我们还测量了内皮细胞损伤的两种标志物，即血清可溶性血栓调节蛋白（sTM）和细胞间粘附分子（ICAM）-1。移植肝脏再灌注后 5 分钟，ExCO-C 显着从基线时的 5.69+/-2.34 ppm 增加至 9.79+/-4.72 ppm (p<0.0001)。 CO浓度增加、再灌注时动脉碳氧血红蛋白水平（r(2)=0.19，p=0.0003）和术后总胆红素水平（第1、2和3天；r(2)=0.102、0.109和0.100；p=0.008、0.007和0.010，分别）。再灌注后血清sTM和ICAM-1水平也显着增加（sTM：3.3+/-0.8至5.1+/-1.7 FU/ml，p=0.0001；ICAM-1：271.9+/-86.3至515.0+/-157.8 FU/ml，p=0.0001）。 ExCO-C 与 sTM (r(2)=0.16, p=0.035) 和 ICAM-1 (r(2)=0.12, p=0.08) 呈正相关。然而，ExCO-C 与血清 AST/ALT 水平或临床结果没有相关性。这项研究表明，LDLT 期间再灌注后 ExCO-C 显着增加。 ExCO-C 的增加可能反映了移植肝脏中血红素分解和内皮细胞损伤的增加。
Exhaled carbon monoxide concentration (ExCO-C) has been reported to increase in oxidative tissue injuries such as systemic inflammation, and is thought to reflect increased heme breakdown in the affected organ. As a transplanted liver undergoes ischemia-reperfusion, we hypothesized that ExCO-C might also increase following liver transplantation and might serve as a measure of the severity of the graft tissue injury. We prospectively studied 67 living donor liver transplantation (LDLT) patients in a consecutive fashion. During anesthesia, ExCO-C was determined at 6 time points, ranging from anesthesia induction, to admission to the intensive care unit. We also measured two markers of endothelial cellular injury, i.e., serum soluble thrombomodulin (sTM) and intercellular adhesion molecule (ICAM)-1. At 5 min after reperfusion of the grafted liver, ExCO-C markedly increased from 5.69+/-2.34 ppm at baseline, to 9.79+/-4.72 ppm (p<0.0001). There was an excellent correlation among an increase in CO concentration, arterial carboxyhemoglobin levels at the time of reperfusion (r(2)=0.19, p=0.0003), and postoperative total bilirubin levels (day 1, 2, and 3; r(2)=0.102, 0.109 and 0.100; p=0.008, 0.007 and 0.010, respectively). Serum sTM and ICAM-1 levels were also significantly increased after reperfusion (sTM: 3.3+/-0.8 to 5.1+/-1.7 FU/ml, p=0.0001; ICAM-1: 271.9+/-86.3 to 515.0+/-157.8 FU/ml, p=0.0001). ExCO-C had a positive relationship with sTM (r(2)=0.16, p=0.035) and ICAM-1 (r(2)=0.12, p=0.08). There was however, no correlation of ExCO-C with serum AST/ALT levels or clinical outcomes. This study demonstrated that ExCO-C significantly increased after reperfusion during LDLT. The increased ExCO-C may likely reflect increased heme breakdown and endothelial cell injury in the grafted liver.
影响因子：
0.9
作者：
Kupiec-Weglinski, JW;Busuttil, RW
通讯作者：
Busuttil, RW
血红素加氧酶亚型对血红素介导的内皮细胞内粘附分子 1 表达的不同影响。
DOI：
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发表时间：
1999
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Wagener,FA;daSilva,JL;Farley,T;deWitte,T;Kappas,A;Abraham,NG
通讯作者：
Abraham,NG
影响因子：
2.9
作者：
Sassa,S
通讯作者：
Sassa,S