European ancestry is positively associated with breast cancer risk in Mexican women.
European ancestry is positively associated with breast cancer risk in Mexican women.
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DOI：
10.1158/1055-9965.epi-09-1193
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发表时间：
2010-04
期刊：
影响因子：
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通讯作者：
Torres-Mejía G
中科院分区：
文献类型：
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作者：
Fejerman L;Romieu I;John EM;Lazcano-Ponce E;Huntsman S;Beckman KB;Pérez-Stable EJ;González Burchard E;Ziv E;Torres-Mejía G
生活在旧金山弗朗西斯科湾区的西班牙裔妇女的乳腺癌发病率比非西班牙裔白色妇女低35%。我们以前描述了一个显着的关联遗传血统和乳腺癌的风险在美国西班牙裔/拉丁裔的样本。我们在居住在墨西哥的妇女中重新测试了这种关联，因为最初的发现可能会被美国特定的未测量的环境暴露所混淆。我们对846名墨西哥乳腺癌妇女和1,035名未受影响的对照者进行了一组106个祖先信息标记（AIM）的基因分型，并使用最大似然法估计了遗传祖先。使用逻辑回归估计作为分类和连续变量建模的血统的比值比（OR）和95%置信区间（CI），并根据生殖和其他已知风险因素进行调整。在这个新的和独立的墨西哥妇女样本中，更大的欧洲血统与乳腺癌风险增加有关。与0-25%欧洲血统的女性相比，51-75%和76-100%欧洲血统的女性风险增加（OR=1.35，95% CI：0.96-1.91和2.44，95% CI：0.94-6.35，趋势p =0.044）。欧洲血统每增加25%（建模为连续变量），乳腺癌风险增加20%（95% CI：1.03-1.41，p=0.019）。这些结果表明，非遗传因素在解释拉丁裔和非拉丁裔白色妇女之间乳腺癌发病率的差异中起着至关重要的作用，它也指出了这种差异的遗传成分的可能性。
The incidence of breast cancer is 35% lower in Hispanic women living in the San Francisco Bay Area than in non-Hispanic white women. We have previously described a significant association between genetic ancestry and risk of breast cancer in a sample of US Hispanics/Latinas. We re-tested the association in women residing in Mexico because of the possibility that the original finding may be confounded by US specific unmeasured environmental exposures. We genotyped a set of 106 ancestry informative markers (AIMs) in 846 Mexican women with breast cancer and 1,035 unaffected controls and estimated genetic ancestry using a maximum likelihood method. Odds ratios (OR) and 95% confidence intervals (CI) for ancestry modeled as a categorical and continuous variable were estimated using logistic regression and adjusted for reproductive and other known risk factors. Greater European ancestry was associated with increased breast cancer risk in this new and independent sample of Mexican women residing in Mexico. Compared to women with 0-25% European ancestry, the risk was increased for women with 51-75% and 76-100% European ancestry (OR=1.35, 95% CI: 0.96-1.91 and 2.44, 95% CI: 0.94-6.35 respectively, p for trend=0.044). For every 25% increase in European ancestry (modeled as a continuous variable) there was a 20% increase in risk of breast cancer (95% CI: 1.03-1.41, p=0.019). These results suggest that non-genetic factors play a crucial role in explaining the difference in breast cancer incidence between Latinas and non-Latina white women and it also points out to the possibility of a genetic component to this difference.