ETHINYL ESTRADIOL ACUTELY ATTENUATES ABNORMAL CORONARY VASOMOTOR RESPONSES TO ACETYLCHOLINE IN POSTMENOPAUSAL WOMEN
ETHINYL ESTRADIOL ACUTELY ATTENUATES ABNORMAL CORONARY VASOMOTOR RESPONSES TO ACETYLCHOLINE IN POSTMENOPAUSAL WOMEN
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DOI：
10.1161/01.cir.89.1.52
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发表时间：
1994-01-01
期刊：
影响因子：
37.8
通讯作者：
BRINKER, JA
中科院分区：
文献类型：
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作者：
REIS, SE;GLOTH, ST;BRINKER, JA
绝经后妇女给予雌激素与冠状动脉疾病临床表现减少50%相关。其机制尚不清楚，尽管一种可能的解释是雌激素诱导的冠状血管反应性调节。乙酰胆碱是一种内皮依赖性血管扩张剂，可用于评估冠状动脉血管反应性，并引起与日常常见血管舒缩刺激相似的冠状动脉反应。因此，我们测试了雌激素是否能减弱绝经后妇女对乙酰胆碱的异常冠状动脉血管舒缩反应。方法与结果测定15例绝经后妇女在静脉注射炔雌醇（eeil, 35 μ g）前和后15分钟，乙酰胆碱引起的冠状动脉血流、阻力和横截面积的变化。雌激素对33名妇女基底冠状动脉血流、阻力和心外膜横截面积的影响也通过测量EE或安慰剂给药前后的这些参数来评估。雌激素改变了22名女性的基底冠状动脉血管舒张性，表现为ee诱导的23.3+/-4.5%（平均+/-SEM）升高(P
Background Estrogen administration in postmenopausal women is associated with a 50% reduction in the clinical manifestations of coronary artery disease. The mechanisms are not known, although one potential explanation is estrogen-induced modulation of coronary vasoreactivity. Acetylcholine is an endothelium-dependent vasodilator that may be used to assess coronary vasoreactivity and elicits coronary responses that parallel those found with common daily vasomotor stimuli. Therefore, we tested whether estrogen attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women.Methods and Results Acetylcholine-induced changes in coronary flow, resistance, and cross-sectional area were determined before and 15 minutes after intravenous administration of ethinyl estradiol (EE, 35 mu g) in 15 postmenopausal women. The influence of estrogen an basal coronary flow, resistance, and epicardial cross-sectional area was also assessed by measuring these parameters before and after EE or placebo administration in 33 women. Estrogen altered basal coronary vasomotor tone in 22 women as manifested by an EE-induced 23.3+/-4.5% (mean+/-SEM) increase (P