CCN2 in Skin Fibrosis
CCN2 in Skin Fibrosis
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DOI：
10.1007/978-1-4939-6430-7_34
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Leask, Andrew
中科院分区：
文献类型：
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作者：
Leask, Andrew
CCN 2，以前称为结缔组织生长因子，于1991年发现。在其发现后不久，CCN 2被证明响应于促纤维化细胞因子转化生长因子（TGF）β而上调，并且在纤维化条件下组成性过表达。这些早期的观察结果导致了CCN 2是纤维化的关键调节因子的假设。然而，直到最近才产生了直接证明这一假设的数据。本文综述了这些观察结果，并提出了CCN 2的作用机制。
CCN2, formerly known as connective tissue growth factor, was discovered in 1991. Soon after its discovery, CCN2 was shown to be upregulated in response to the profibrotic cytokine transforming growth factor (TGF) beta and to be constitutively overexpressed in fibrotic conditions. These early observations led to the hypothesis that CCN2 was a key regulator of fibrosis. However, only recently have data been generated that directly demonstrate this hypothesis. This review summarizes these observations and suggests a mechanism of action for CCN2.