Intraprocedural Ablation Margin Assessment by Using Ammonia Perfusion PET during FDG PET/CT-guided Liver Tumor Ablation: A Pilot Study
Intraprocedural Ablation Margin Assessment by Using Ammonia Perfusion PET during FDG PET/CT-guided Liver Tumor Ablation: A Pilot Study
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DOI：
10.1148/radiol.2018172108
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发表时间：
2018-07-01
期刊：
影响因子：
19.7
通讯作者：
Silverman, Stuart G.
中科院分区：
文献类型：
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作者：
Shyn, Paul B.;Casadaban, Leigh C.;Silverman, Stuart G.
目的：前瞻性地确定在氟18氟脱氧葡萄糖（FDG）PET/计算机断层扫描（CT）引导的肝脏肿瘤消融术期间是否可以使用氮13（N-13）氨灌注正电子发射断层扫描（PET）来术中评估消融边缘。研究对象为11例（5名女性和3名男性;年龄范围：36-74岁;平均年龄：57岁），在FDG PET/CT引导下微波消融11例FDG阳性肝转移瘤。（平均直径，22 mm;范围，11-34 mm）。所有手术均在2014年3月至2016年12月期间进行。由两名独立的盲态放射科医生使用术中N-13-氨灌注PET与术后24小时MR成像进行比较，评估完全消融边缘可见性和最小消融边缘厚度。在随访成像3-38个月（中位数，17.6个月）时评估每个消融肿瘤的局部肿瘤进展。结果：11个（100%）消融利润率是完全可评估的，通过使用术中灌注PET的两个读者; 11个（55%）利润率是完全可评估的两个读者在术后24小时MR成像。通过使用灌注PET，一个被两个阅片者判定为最小边缘为0 mm的肿瘤局部进展。没有肿瘤判断有一个最小的利润大于0毫米在灌注PET进展local.Conclusion：N-13-氨灌注PET在FDG PET/CT引导下的肝肿瘤消融术可以潜在地被用来intraprocedurally评估整个消融边缘，包括最小利润。(c)RSNA，2018
Purpose: To prospectively determine whether nitrogen 13 (N-13) ammonia perfusion positron emission tomography (PET) during fluorine 18 fluorodeoxyglucose (FDG) PET/computed tomography (CT)-guided liver tumor ablation can be used to intraprocedurally assess ablation margins.Materials and Methods: Eight patients (five women and three men; age range, 36-74 years; mean age, 57 years) were enrolled in this pilot study and underwent FDG PET/CT-guided microwave ablation of 11 FDG-avid liver metastases (mean diameter, 22 mm; range, 11-34 mm). All procedures were performed between March 2014 and December 2016. Complete ablation margin visibility and minimum ablation margin thickness were assessed by using intraprocedural N-13-ammonia perfusion PET compared with 24-hour postprocedural MR imaging by two independent blinded radiologists. Local tumor progression for each ablated tumor was assessed at follow-up imaging for 3-38 months (median, 17.6 months). Descriptive analysis was performed.Results: Eleven of 11 (100%) ablation margins were fully assessable by using intraprocedural perfusion PET by both readers; six of eleven (55%) margins were fully assessable by both readers at postprocedural 24-hour MR imaging. By using perfusion PET, one tumor that had been judged by both readers to have a minimum margin of 0 mm progressed locally. No tumors judged to have a minimum margin greater than 0 mm at perfusion PET progressed locally.Conclusion: N-13-ammonia perfusion PET during FDG PET/CT-guided liver tumor ablations can potentially be used to intraprocedurally assess the entire ablation margin, including the minimum margin. (c) RSNA, 2018