Heritability of heart rate variability - The Framingham Heart Study
Heritability of heart rate variability - The Framingham Heart Study
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DOI：
10.1161/01.cir.99.17.2251
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发表时间：
1999-05-04
期刊：
影响因子：
37.8
通讯作者：
Levy, D
中科院分区：
文献类型：
--
作者：
Singh, JP;Larson, MG;Levy, D
背景——不断有证据表明心率 (HR) 是由基因决定的。通过功率谱分析测量的心率变异性 (HRV) 提供了自主神经系统活动的定量表型标记。报告的 HR 和 HRV 决定因素仅部分解释了它们在人群中的变异性。本研究的目的是评估 HR 和 HRV 的遗传力，并估计遗传因素对其方差的贡献。方法和结果——在常规检查中接受动态记录的受试者符合条件；患有充血性心力衰竭、冠状动脉疾病、糖尿病和服用心脏活性药物的受试者被排除在外。我们分析了 2 小时连续心电图记录的高频功率、低频功率、极低频功率、总功率、低频/高频比以及正常 R-R 间隔的标准偏差。在调整重要协变量后，通过研究兄弟姐妹（n = 682，291 个兄弟姐妹，517 对）之间和配偶对之间（n = 206 对）之间的相关性来进行遗传力分析。组合不同模型的结果来估计可归因于测量的协变量、加性遗传效应（遗传力）和家庭效应的方差分量。调整协变量后，兄弟姐妹之间的相关性（0.21 至 0.26）始终高于配偶之间的相关性（0.01 至 0.19）。测得的协变量一般占总表型方差的 13% 至 40%，而遗传因素占 HR 和 HRV 测量变异的 13% 至 23%。 结论——遗传因素可以解释 HR 和 HRV 方差的很大一部分。这些结果强调了遗传因素与环境因素对自主神经系统活动的影响。
Background-There is evolving evidence that heart rate (HR) is genetically determined. Heart rate variability (HRV) measured by power spectral analysis provides quantitative phenotypic markers of autonomic nervous system activity. Reported determinants of HR and HRV only partially explain their variability in the population. The purpose of this study was to assess the heritability of HR and HRV and estimate the contribution of genetic factors to their variance.Methods and Results-Subjects who underwent ambulatory recordings at a routine examination were eligible; subjects with congestive heart failure, coronary artery disease, diabetes mellitus, and those taking cardioactive medications were excluded. We analyzed high-frequency power, low-frequency power, very low-frequency power, total power, low-frequency/high-frequency ratio, and the standard deviation of normal R-R intervals from 2-hour continuous ECG recordings. Heritability analysis was done by studying correlations between siblings (n = 682, in 291 sibships, 517 pairs) and between spouse pairs (n = 206 pairs) after adjusting for important covariates. Results from separate models were combined to estimate the components of variance attributable to measured covariates, additive genetic effects (heritability), and household effects. After adjusting for covariates, the correlations were consistently higher among siblings (0.21 to 0.26) compared with spouses (0.01 to 0.19). The measured covariates in general accounted for 13% to 40% of the total phenotypic variance, whereas genetic factors accounted for 13% to 23% of the variation among HR and HRV measures.Conclusions-Heritable factors may explain a substantial proportion of the variance in HR and HRV. These results highlight the contribution of genetic versus environmental factors to autonomic nervous system activity.