Sequential EEG analysis during intermittent photic stimulation in never-medicated patients with schizophrenia
Sequential EEG analysis during intermittent photic stimulation in never-medicated patients with schizophrenia
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DOI：
10.1177/155005940303400407
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发表时间：
2003-10-01
期刊：
影响因子：
--
通讯作者：
Koshino, Y
中科院分区：
文献类型：
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作者：
Kikuchi, M;Wada, Y;Koshino, Y
为了研究间歇性光刺激（IPS）过程中脑电图（EEG）的连续变化，对18例药物初治精神分裂症患者和18例性别和年龄匹配的对照组进行了α波段（与刺激频率相关）的定量EEG分析。IPS由白色闪烁组成，闪烁速度为10次/秒，持续10秒，并以10秒的间隔重复6次。针对两种情况评估两组之间的差异（即，在光刺激（PS）和PS间）。在刺激过程中，患者组的9-11 Hz频带的绝对功率在整个10秒期间在后部高于前部。然而，在对照组的前1秒内，未观察到部位之间的这种差异。在非刺激期间，9-11 Hz频带功率的后验优势在患者组中始终突出。然而，在对照组中，这种差异很小，特别是在这段时间的后半段。这些结果表明，精神分裂症患者在刺激和非刺激期间后α活动的变化较少，这种后优势的连续性可能反映了过度觉醒，这抵消了整个IPS的警惕性下降。
To investigate sequential changes in electroencephalograms (EEGs) during intermittent photic stimulation (IPS), quantitative EEG analysis for the alpha band (related to stimulus frequency) was performed in 18 drug-naive schizophrenic patients and 18 sex- and age-matched control subjects. IPS consisted of white flickers at 10 flashes/sec, lasting 10 sec and repeated six times at 10 sec intervals. The differences between the two groups were assessed for two conditions (i.e., during photic stimulation (PS) and inter-PS). During stimulus, the absolute 9-11 Hz band power of the patient group was higher at the posterior than that at the anterior sites throughout the 10 sec periods. However, this difference between sites was not seen during the first 1 sec in the control group. During the nonstimulus period, posterior dominance of 9-11 Hz band power was prominent in the patient group throughout. In the control group, however, this difference was minor, especially during the latter half of the period. These results suggest that schizophrenic patients show fewer changes in posterior alpha activity during both stimulus and nonstimulus, and this continuity of posterior dominance may reflect hyper-arousal, which counteracts any decrease in vigilance throughout the IPS.