Aryne-Induced SNAr/Dearylation Strategy for the Synthesis of Fluorinated Dibenzophospholes from Triarylphosphines via a P(V) Intermediate
Aryne-Induced SNAr/Dearylation Strategy for the Synthesis of Fluorinated Dibenzophospholes from Triarylphosphines via a P(V) Intermediate
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DOI：
10.1021/acs.orglett.0c00489
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发表时间：
2020-03-20
期刊：
影响因子：
5.2
通讯作者：
Tobisu, Mamoru
中科院分区：
文献类型：
--
作者：
Fujimoto, Hayato;Kusano, Momoka;Tobisu, Mamoru
报道了一种以三芳基膦为原料，通过芳炔脱芳基成环反应合成含氟二苯并磷杂环戊二烯的方法。这种分子间的成环作用允许从简单的结构单元制备各种氟化二苯并磷杂环戊烯。这种脱芳基成环反应成功的关键是形成五配位的四芳基氟磷烷。在这项工作中，我们成功地合成了稳定的四芳基氟磷烷，其结构是明确确定的X射线晶体学。
We report on a method for the synthesis of fluorinated dibenzophospholes using triarylphosphine via dearylative annulation with an aryne. This intermolecular annulation allows the preparation of a variety of fluorinated dibenzophospholes from simple building blocks. The key to the success of this dearylative annulation is the formation of a five-coordinated tetraarylfluorophosphorane. In this work, we successfully synthesized stable tetraarylfluorophosphorane, the structure of which was unambiguously determined by X-ray crystallography.