A seronegative case of HIV-1 subtype C infection in Botswana.
A seronegative case of HIV-1 subtype C infection in Botswana.
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博茨瓦纳一例 HIV-1 C 亚型感染血清阴性病例。
DOI：
10.1086/520683
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Essex,M
中科院分区：
文献类型：
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作者：
Novitsky,Vladimir;Gaolathe,Tendani;Woldegabriel,Elias;Makhema,Joseph;Essex,M
据我们所知，我们报告了首例抗体阴性人类免疫缺陷病毒 1 型 (HIV-1) C 亚型感染病例，该病例是在博茨瓦纳筛查急性 HIV-1 感染期间发现的。 HIV-1 抗体检测结果始终呈阴性，包括快速和常规酶联免疫吸附测定和蛋白质印迹。非重组 HIV-1 C 亚型感染通过 gag、pol 和 env 基因内的病毒基因分型得到证实。从临床病情稳定的患者转诊到与艾滋病相关的死亡之间的时间间隔约为 3 个月。报告的病例表明了研究南部非洲血清阴性 HIV-1 感染流行情况的重要性，该地区 C 亚型占主导地位。
We report the first case, to our knowledge, of antibody-negative human immunodeficiency virus type 1 (HIV-1) subtype C infection, which was identified during screening for acute HIV-1 infection in Botswana. Results of tests for HIV-1 antibodies were consistently negative, including rapid and regular enzyme-linked immunosorbent assay and Western blot. The nonrecombinant HIV-1 subtype C infection was confirmed by viral genotyping within thegag, pol, andenvgenes. The period between referral of the patient in a clinically stable condition and AIDS-related death was ∼3 months. The reported case indicates the importance of studying the prevalence of seronegative HIV-1 infection in southern Africa, where subtype C predominates.