Metabolic Tumor Volumes by [18F]-Fluorodeoxyglucose PET/CT Correlate with Occult Metastasis in Oral Squamous Cell Carcinoma of the Tongue
Metabolic Tumor Volumes by [18F]-Fluorodeoxyglucose PET/CT Correlate with Occult Metastasis in Oral Squamous Cell Carcinoma of the Tongue
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DOI：
10.1245/s10434-009-0621-3
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发表时间：
2009-11-01
影响因子：
3.7
通讯作者：
Baek, Chung-Hwan
中科院分区：
文献类型：
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作者：
Chung, Man Ki;Jeong, Han-Sin;Baek, Chung-Hwan
探讨[F-18]-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（PET/CT）测定的预处理代谢肿瘤体积（MTV）与舌口腔鳞状细胞癌（OSCC）隐匿转移（OM）的相关性。纳入43例临床淋巴结阴性（cN0）的OSCC患者，通过术前检查（活检、体格检查、CT和PET/CT）诊断。所有患者均行原发肿瘤切除术和择期颈部清扫术。通过自动轮廓程序测量显示标准摄取值（SUV）为bbbb2.5的肿瘤的mtv。分析治疗前变量（年龄、性别、临床T分期、最大SUV [SUVmax]和MTV）和治疗后变量（病理T分期、浸润深度、淋巴血管浸润、病理肿瘤体积、组织学分化）与OM的相关性。43例患者中有12例（27.9%）在颈部解剖病理标本中发现OM。6.0 ml的MTV被确定为预测OM的最具判别性的值。单因素分析发现，MTV为bbb6.0 ml的患者隐匿性转移的数量明显高于MTV为千分之一货币标志6.0 ml的患者（57.1% vs. 13.7%，风险比8.33,95%可信区间，1.95 ~ 35.6,P = 0.009）。淋巴血管侵袭和SUVmax仅呈显著趋势（P分别为0.08和0.05）。多因素分析显示，只有MTV与OM有显著相关（风险比54.66,95%可信区间1.05 ~ 2842.86,P = 0.04）。PET/CT检测的MTV与舌部cN0型OSCC患者的OM有统计学意义。
To investigate the correlation between pretreatment metabolic tumor volume (MTV) as determined by [F-18]-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and occult metastasis (OM) in oral squamous cell carcinoma (OSCC) of the tongue.Forty-three clinically node-negative (cN0) OSCC patients, diagnosed by preoperative workups (biopsy, physical examination, CT, and PET/CT) were enrolled. All patients had undergone primary tumor resections and elective neck dissections. MTVs were measured for tumors showing standardized uptake value (SUV) of > 2.5 by an automated contouring program. Pretreatment variables (age, sex, clinical T stage, maximal SUV [SUVmax] and MTV) and posttreatment variables (pathologic T stage, depth of invasion, lymphovascular invasion, pathologic tumor volume, and histological differentiation) were analyzed to identify their correlation with OM.Twelve (27.9%) of 43 patients were found to have OM in pathologic specimen of neck dissections. A cutoff of 6.0 ml for the MTV was determined to be the most discriminative value for predicting OM. By univariate analysis, the patients with an MTV of > 6.0 ml had significantly higher number of occult metastases than those with an MTV of a parts per thousand currency sign6.0 ml (57.1% vs. 13.7%, hazard ratio 8.33, 95% confidence interval, 1.95-35.6, P = 0.009). Lymphovascular invasion and SUVmax showed only trends toward significance (P = 0.08 and 0.05, respectively). By multivariate analysis, only MTV had a significant correlation with OM (hazard ratio 54.66, 95% confidence interval, 1.05-2842.86, P = 0.04).MTV as determined by PET/CT demonstrated a statistically significant correlation with OM in patients with cN0 OSCC of the tongue.