Signalling to cancer cell invasion through PAK family kinases
Signalling to cancer cell invasion through PAK family kinases
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DOI：
10.2741/3724
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发表时间：
2011-01-01
影响因子：
3.1
通讯作者：
Wells, Claire M.
中科院分区：
文献类型：
--
作者：
Whale, Andrew;Hashim, Fariesha Nur;Wells, Claire M.
癌细胞转移涉及由致癌转化驱动的一系列细胞行为变化，导致局部组织侵袭、通过细胞外基质迁移、进入血管或淋巴系统以及远处部位的定植。众所周知，Rho 家族 GTPases Rho、Rac 和 Cdc42 协调了转移过程中所需的许多过程。 Rho 家族 GTP 酶通过与下游效应蛋白的相互作用来调节细胞行为。 p-21 激活激酶 (PAK) 是 Rac 和 Cdc42 的效应蛋白，已知是细胞迁移和侵袭的重要调节因子。哺乳动物 PAK 有六种，可分为两组：I 组 PAK (PAK1-3) 和 II 组 PAK (PAK4-6)。尽管这两个 PAK 组在结构上相似，但它们的调节模式存在差异，这表明它们的细胞功能可能不同。本综述将重点关注与 PAK 家族激酶在驱动癌细胞迁移和侵袭的细胞信号通路中的作用相关的最新证据。
Cancer cell metastasis involves a series of changes in cell behaviour, driven by oncogenic transformation, that leads to local tissue invasion, migration through extracellular matrix, entry into the vascular or lymphatic system and colonisation of distant sites. It is well established that the Rho family GTPases Rho, Rac and Cdc42 orchestrate many of the processes required during metastasis. The Rho family GTPases regulate cellular behaviour through their interaction with downstream effector proteins. The p-21 activated kinases (PAKs), effector proteins for Rac and Cdc42, are known to be important regulators of cell migration and invasion. There are six mammalian PAKs which can be divided into two groups: group I PAKs (PAK1-3) and group II PAKs (PAK4-6). Although the two PAK groups are architecturally similar there are differences in their mode of regulation suggesting their cellular functions are likely to be different. This review will focus on the latest evidence relating to the role of PAK family kinases in the cell signalling pathways that drive cancer cell migration and invasion.