Seminal vesicle protein SVS2 is required for sperm survival in the uterus
Seminal vesicle protein SVS2 is required for sperm survival in the uterus
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DOI：
10.1073/pnas.1320715111
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发表时间：
2014-03-18
影响因子：
11.1
通讯作者：
Umezawa, Akihiro
中科院分区：
文献类型：
--
作者：
Kawano, Natsuko;Araki, Naoya;Umezawa, Akihiro
在哺乳动物中，精子通过雌性生殖道到达卵子；然而，我们对这段旅程的理解非常有限。为了阐明这一过程，我们重点研究了精囊分泌2 （SVS2）的功能。SVS2（-/-）雄性小鼠产生精子，但严重不育，并且没有形成覆盖雌性生殖器开口的交配塞。令人惊讶的是，即使用硅代替塞进行人工授精，在没有SVS2的情况下，精子的生育能力仍然严重降低，因为精子在子宫中已经死亡。因此，我们的结果提供了子宫诱导精子细胞死亡和SVS2保护精子免受子宫攻击的证据。
In mammals, sperm migrate through the female reproductive tract to reach the egg; however, our understanding of this journey is highly limited. To shed light on this process, we focused on defining the functions of seminal vesicle secretion 2 (SVS2). SVS2(-/-) male mice produced sperm but were severely subfertile, and formation of a copulatory plug to cover the female genital opening did not occur. Surprisingly, even when artificial insemination was performed with silicon as a substitute for the plug, sperm fertility in the absence of SVS2 remained severely reduced because the sperm were already dead in the uterus. Thus, our results provide evidence that the uterus induces sperm cell death and that SVS2 protects sperm from uterine attack.