Serial plasma concentrations of PYY and ghrelin during chemotherapy in children with acute lymphoblastic leukemia
Serial plasma concentrations of PYY and ghrelin during chemotherapy in children with acute lymphoblastic leukemia
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DOI：
10.1097/mph.0b013e318179a1d8
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发表时间：
2008-10-01
影响因子：
1.2
通讯作者：
Tzortzatou-Stathopoulou, Fotini
中科院分区：
文献类型：
--
作者：
Moschovi, Maria;Trimis, Georgios;Tzortzatou-Stathopoulou, Fotini
目的：探讨肽YY（PYY）和生长激素释放肽分泌，在诊断和化疗期间在儿童急性淋巴细胞白血病（ALL）患者和方法：测量进行诊断，诱导巩固阶段后，在每个周期前的标准时间点在9例ALL患者年龄2至7岁（中位数4.3岁）。体重指数（BMI）和白血病负荷在同一时间点进行估计，并与PYY和ghrelin水平相关。结果：与正常对照组比较，确诊时PYY水平明显升高（P < 0.0001），而Ghrelin活性明显降低（P <0.001），与正常对照组比较，P <0.001。
Purpose: To investigate peptide YY (PYY) and ghrelin secretion, at diagnosis and during chemotherapy in children with acute lymphoblastic leukemia (ALL).Patients and Methods: Measurements were performed at diagnosis, after the induction-consolidation phase and at standard time points before each cycle in 9 patients with ALL aged 2 to 7 years (median 4.3 y). Body mass index (BMI) and leukemic burden were estimated at the same time points and correlated with PYY and ghrelin levels. Nine healthy children matched for age and sex were used as controls.Results: At diagnosis, mean PYY levels were high (P < 0.0001) and mean active ghrelin were low, compared with controls (P