Mitochondrial STAT3: Powering up a potent factor
Mitochondrial STAT3: Powering up a potent factor
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DOI：
10.1016/j.cyto.2016.05.019
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发表时间：
2016-11-01
期刊：
影响因子：
3.8
通讯作者：
Gough, Daniel J.
中科院分区：
文献类型：
--
作者：
Garama, Daniel J.;White, Christine L.;Gough, Daniel J.
JAK-STAT 3信号通路被许多细胞因子和生长因子刺激物参与以控制多种生物过程，包括增殖、血管生成、存活、免疫调节和代谢。二十多年来，人们已经接受STAT 3依赖性生物学是由于其作为能够调节数百个基因表达的转录因子的效力。然而，最近出现了STAT 3的非规范和非基因组活性的证据。这些活动中最令人兴奋的是其转运到线粒体中的能力，在那里它调节电子传递链的活性和线粒体渗透性转换孔的打开。这些具有广泛的后果，包括正常组织和病理条件下的细胞存活和活性氧和ATP的产生。尽管有这些有趣的观察结果，但关于STAT线粒体活性的机制仍有许多关键的未解之谜。(C)2016爱思唯尔有限公司版权所有
The JAK-STAT3 signaling pathway is engaged by many cytokines and growth factor stimuli to control diverse biological processes including proliferation, angiogenesis, survival, immune modulation, and metabolism. For over two decades it has been accepted that STAT3-dependent biology is due to its potency as a transcription factor capable of regulating the expression of many hundreds of genes. However, recent evidence of non-canonical and non-genomic activities of STAT3 has emerged. The most exciting of these activities is its capacity to translocate into the mitochondria where it regulates the activity of the electron transport chain and the opening of the mitochondrial permeability transition pore. These have broad consequences including cell survival and the production of reactive oxygen species and ATP in both normal tissue and under pathological conditions. Despite these fascinating observations there are many key unanswered questions about the mechanism of STAT mitochondrial activity. (C) 2016 Elsevier Ltd. All rights reserved.