Total Synthesis of (-)-Polycavernoside A: Suzuki-Miyaura Coupling Approach
Total Synthesis of (-)-Polycavernoside A: Suzuki-Miyaura Coupling Approach
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(-)-Polycavernoside A 的全合成：Suzuki-Miyaura 偶联法
DOI：
10.1021/ol301278e
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Makoto Sasaki
中科院分区：
文献类型：
--
作者：
Yusuke Kasai;Takanori Ito;Makoto Sasaki
从食用藻类Gracilaria edulis中分离出的一种海洋致死毒素(−)-聚海绵糖苷A已通过收敛方法实现了全合成。重点是两个关键片段的催化不对称合成以及它们通过Suzuki-Miyaura偶联和Keck大内酯化而结合。
A total synthesis of (−)-polycavernoside A, a marine lethal toxin isolated from the edible alga Gracilaria edulis, has been achieved via a convergent approach. The synthesis is highlighted by catalytic asymmetric syntheses of the two key fragments and their union through Suzuki–Miyaura coupling and Keck macrolactonization.