Uridine transport and RNA synthesis in growing and in density‐inhibited animal cells
Uridine transport and RNA synthesis in growing and in density‐inhibited animal cells
复制标题
生长中和密度抑制动物细胞中的尿苷转运和 RNA 合成
DOI：
10.1002/jcp.1040770205
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发表时间：
1971
影响因子：
5.6
通讯作者：
H. Rubin
中科院分区：
文献类型：
--
作者：
M. Weber;H. Rubin
鸡胚成纤维细胞和小鼠3T3细胞在高细胞密度下生长受到抑制，它们将H3尿苷掺入RNA的速率降低。这种减少是细胞种群密度的函数，在鸡胚胎细胞中（与3T3细胞相反），它不伴随着显著的培养基改变。这表明细胞种群密度在控制细胞代谢中的重要性。
Both chick embryo fibroblasts and mouse 3T3 cells reduce the rate at which they incorporate H3 uridine into RNA as their growth becomes inhibited at high cell density. This reduction occurs as a function of the cell population density, and with chick embryo cells (in contrast to 3T3 cells) it is not accompanied by significant medium alterations. This indicates the importance of the cell population density in the control of cellular metabolism.