Comparison of the removal of uraemic toxins with medium cut-off and high-flux dialysers: a randomized clinical trial
Comparison of the removal of uraemic toxins with medium cut-off and high-flux dialysers: a randomized clinical trial
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DOI：
10.1093/ndt/gfz189
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发表时间：
2020-02-01
影响因子：
6.1
通讯作者：
Bridoux, Frank
中科院分区：
文献类型：
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作者：
Belmouaz, Mohamed;Bauwens, Marc;Bridoux, Frank
血液透析（HD）患者中中等体重尿毒症毒素的蓄积导致发病率和死亡率增加。方法本交叉前瞻性研究包括40例患者，随机分为两组，一组接受中等截留量HD（MCO-HD），另一组接受高通量HD（HF-HD），反之亦然。主要终点为MCO-HD治疗3个月后的肌红蛋白降低率（RR）。次要终点是MCO-HD对其他中等重量毒素和蛋白质结合毒素以及营养、炎症、贫血和氧化应激参数的影响。结果与HF-HD相比，MCO-HD提供了更高的肌红蛋白平均RR（368 vs 57 +/-13%，P
Background Accumulation of middle-weight uraemic toxins in haemodialysis (HD) patients results in increased morbidity and mortality. Whether medium cut-off HD (MCO-HD) improves removal of middle-weight uraemic toxins remains to be demonstrated.Methods This cross-over prospective study included 40 patients randomly assigned to receive either 3months of MCO-HD followed by 3months of high-flux HD (HF-HD), or vice versa. The primary endpoint was myoglobin reduction ratio (RR) after 3months of MCO-HD. Secondary endpoints were the effect of MCO-HD on other middle-weight toxins and protein-bound toxins, and on parameters of nutrition, inflammation, anaemia and oxidative stress.Results Compared with HF-HD, MCO-HD provided higher mean RR of myoglobin (368 versus 57 +/- 13%, P