The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
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DOI：
10.1016/j.cell.2004.11.003
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发表时间：
2004-12-17
期刊：
影响因子：
64.5
通讯作者：
Sheng, M
中科院分区：
文献类型：
--
作者：
Li, Z;Okamoto, K;Sheng, M
线粒体在细胞内的适当分布被认为对神经元细胞的正常生理至关重要，但这一观点缺乏直接证据。线粒体向树突状突起的延伸或运动与脊柱的发育和形态可塑性有关。通过对动力蛋白样gtpase Drp1和OPA1的分子操作，减少树突线粒体的含量，导致突触和树突棘的丢失，而增加树突线粒体含量或线粒体活性，则增加了棘和突触的数量和可塑性。因此，线粒体的树突状分布对突触的支持是必要的和限制的。反过来，突触活动调节线粒体的运动和融合/裂变平衡，并控制线粒体在树突中的分布。
The proper intracellular distribution of mitochondria is assumed to be critical for normal physiology of neuronal cells, but direct evidence for this idea is lacking. Extension or movement of mitochondria into dendritic protrusions correlates with the development and morphological plasticity of spines. Molecular manipulations of dynamin-like GTPases Drp1 and OPA1 that reduce dendritic mitochondria content lead to loss of synapses and dendritic spines, whereas increasing dendritic mitochondrial content or mitochondrial activity enhances the number and plasticity of spines and synapses. Thus, the dendritic distribution of mitochondria is essential and limiting for the support of synapses. Reciprocally, synaptic activity modulates the motility and fusion/fission balance of mitochondria and controls mitochondrial distribution in dendrites.