The safety of asthma medications during pregnancy and lactation: Clinical management and research priorities.
The safety of asthma medications during pregnancy and lactation: Clinical management and research priorities.
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妊娠期和哺乳期哮喘药物的安全性：临床管理和研究重点。
DOI：
10.1016/j.jaci.2021.02.037
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Schatz M
中科院分区：
文献类型：
--
作者：
Chambers CD;Krishnan JA;Alba L;Albano JD;Bryant AS;Carver M;Cohen LS;Gorodetsky E;Hernandez-Diaz S;Honein MA;Jones BL;Murray RK;Namazy JA;Sahin L;Spong CY;Vasisht KP;Watt K;Wurst KE;Yao L;Schatz M
哮喘是育龄妇女最常见的基础疾病之一，在怀孕和哺乳期间可能导致严重的医疗问题。邀请多个相关学科的一组关键利益攸关方参与努力，确定优先顺序，制定战略，并动员行动步骤，以填补在怀孕和哺乳期间哮喘药物安全知识方面的重要空白。利益相关者发现了在怀孕和哺乳期间使用的哮喘药物安全性方面的文献中存在的重大差距，并确定了填补这些差距的优先战略。短期行动步骤包括将现有补充研究设计的数据联系起来(美国和国际索赔数据、单一药物怀孕登记、病例对照研究和协调的系统数据系统)。长期行动步骤包括创建哮喘疾病登记处，将疾病登记处纳入电子健康记录系统，以及协调跨学科的护理。利益攸关方还优先考虑建立新的基础设施/合作，以在孕妇和哺乳期妇女中进行研究，并在整个过程中纳入患者的观点。为了填补证据空白，并帮助用为临床决策提供信息的数据填充产品标签，该联盟制定了一项计划，以最有效和及时的方式系统地获得必要的数据。
Asthma is one of the most common underlying diseases in women of reproductive age that can lead to potentially serious medical problems during pregnancy and lactation. A group of key stakeholders across multiple relevant disciplines was invited to take part in an effort to prioritize, strategize, and mobilize action steps to fill important gaps in knowledge regarding asthma medication safety in pregnancy and lactation. The stakeholders identified substantial gaps in the literature on the safety of asthma medications used during pregnancy and lactation and prioritized strategies to fill those gaps. Short-term action steps included linking data from existing complementary study designs (US and international claims data, single drug pregnancy registries, case-control studies, and coordinated systematic data systems). Long-term action steps included creating an asthma disease registry, incorporating the disease registry into electronic health record systems, and coordinating care across disciplines. The stakeholders also prioritized establishing new infrastructures/collaborations to perform research in pregnant and lactating women and to include patient perspectives throughout the process. To address the evidence gaps, and aid in populating product labels with data that inform clinical decision making, the consortium developed a plan to systematically obtain necessary data in the most efficient and timely manner.
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