Human Gastrointestinal Neoplasia‐Associated Myofibroblasts Can Develop from Bone Marrow‐Derived Cells Following Allogeneic Stem Cell Transplantation
Human Gastrointestinal Neoplasia‐Associated Myofibroblasts Can Develop from Bone Marrow‐Derived Cells Following Allogeneic Stem Cell Transplantation
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DOI：
10.1002/stem.63
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发表时间：
2009-06
期刊：
影响因子：
5.2
通讯作者：
D. Worthley;A. Ruszkiewicz;R. Davies;S. Moore;I. Nivison‐Smith;L. Bik To;P. Browett;R. Western;S. Durrant;J. So;G. Young;C. Mullighan;P. Bardy;M. Michael
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文献类型：
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作者：
D. Worthley;A. Ruszkiewicz;R. Davies;S. Moore;I. Nivison‐Smith;L. Bik To;P. Browett;R. Western;S. Durrant;J. So;G. Young;C. Mullighan;P. Bardy;M. Michael
本研究描述了骨髓源性细胞对人类肿瘤和腹膜间质的贡献。澳大拉西亚骨髓移植登记处被用来识别男性异基因干细胞移植的女性受者中发生的实体器官肿瘤。18个合适的情况下，包括几个皮肤癌，两个胃癌，和一个直肠腺瘤。光镜，荧光和显色原位杂交，免疫组织化学进行，以确定肿瘤和基质细胞的性质和起源。与最近的报告相反，未检测到供体来源的肿瘤细胞。然而，在直肠腺瘤和胃癌中发现了骨髓源性肿瘤相关肌成纤维细胞。在人胃肠道肿瘤的背景下，骨髓源性细胞可以产生肌成纤维细胞。干细胞2009;27：1463-1468
This study characterized the contribution of bone marrow‐derived cells to human neoplasia and the perineoplastic stroma. The Australasian Bone Marrow Transplant Recipient Registry was used to identify solid organ neoplasia that developed in female recipients of male allogeneic stem cell transplants. Eighteen suitable cases were identified including several skin cancers, two gastric cancers, and one rectal adenoma. Light microscopy, fluorescence and chromogenic in situ hybridization, and immunohistochemistry were performed to determine the nature and origin of the neoplastic and stromal cells. In contrast to recent reports, donor‐derived neoplastic cells were not detected. Bone marrow‐derived neoplasia‐associated myofibroblasts, however, were identified in the rectal adenoma and in a gastric cancer. Bone marrow‐derived cells can generate myofibroblasts in the setting of human gastrointestinal neoplasia. STEM CELLS 2009;27: 1463–1468