Whole body energy expenditure and fuel oxidation after 2,5-anhydro-D-mannitol administration.
Whole body energy expenditure and fuel oxidation after 2,5-anhydro-D-mannitol administration.
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2,5-脱水-D-甘露醇给药后全身能量消耗和燃料氧化。
DOI：
10.1152/ajpregu.1995.268.1.r299
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Woods,SC
中科院分区：
文献类型：
--
作者：
Park,CR;Seeley,RJ;Benthem,L;Friedman,MI;Woods,SC
果糖类似物2，5-脱水-D-甘露醇（2，5-AM）增加非剥夺大鼠的摄食量。几条证据表明，来自肝脏的迷走神经信号对这种效应至关重要。此外，2，5-AM降低血糖并增加脂解，导致血浆游离脂肪酸和酮体增加。在这些方面，2，5-AM产生类似于食物剥夺后观察到的状态。使用间接量热计，我们确定2，5-AM（300 mg/kg ip）导致呼吸商的有效和持久的降低，表明来自碳水化合物氧化的总能量部分减少，来自脂肪酸氧化的部分增加。这些代谢变量的改变不影响总代谢率。该剂量的类似物也比注射媒介物刺激显著更大的食物摄入。这些结果支持继续使用2，5-AM作为探索食物摄入的代谢控制的工具。
The fructose analogue 2,5-anhydro-D-mannitol (2,5-AM) increases food intake in nondeprived rats. Several lines of evidence indicate that vagal signals arising from the liver are critical for this effect. In addition, 2,5-AM decreases plasma glucose and increases lipolysis, resulting in an increase in plasma free fatty acids and ketone bodies. In these respects 2,5-AM produces a state analogous to that observed after food deprivation. Using an indirect calorimeter, we determined that 2,5-AM (300 mg/kg ip) causes a potent and long-lasting decrease in respiratory quotient, indicating a decrease in the fraction of total energy derived from carbohydrate oxidation and an increase in the fraction derived from fatty acid oxidation. These metabolic variables were altered without affecting total metabolic rate. This dose of analogue also stimulated significantly greater food intake than injections of vehicle. These results support the continued use of 2,5-AM as a tool to probe the metabolic controls of food intake.