Niobium‐Catalyzed Highly Enantioselective Aza‐Diels—Alder Reactions.
Niobium‐Catalyzed Highly Enantioselective Aza‐Diels—Alder Reactions.
复制标题
铌催化的高度对映选择性氮杂二烯-阿尔德反应。
DOI：
10.1002/chin.200832144
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
S. Kobayashi
中科院分区：
文献类型：
--
作者：
Václav Jurčík;K. Arai;M. Salter;Y. Yamashita;S. Kobayashi
铌基手性刘易斯酸被发现是亚胺与Danishefsky双烯的氮杂-Diels-Alder反应的高效催化剂。该反应对芳香族和脂肪族亚胺都具有高产率和高对映选择性。将该方法应用于（+）-假木贼碱的全合成。
Niobium‐based chiral Lewis acid was found to be highly effective catalyst for aza‐Diels–Alder reactions of imines with Danishefsky‘s dienes. The reactions proceed in high yield with high enantioselectivity for both aromatic and aliphatic imines. The developed methodology was applied to total synthesis of (+)‐anabasine.