Oxytocin modulates dopamine-mediated reward in the rat subthalamic nucleus
Oxytocin modulates dopamine-mediated reward in the rat subthalamic nucleus
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DOI：
10.1016/j.yhbeh.2012.12.003
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发表时间：
2013-02-01
影响因子：
3.5
通讯作者：
Cornish, Jennifer L.
中科院分区：
文献类型：
--
作者：
Baracz, Sarah J.;Cornish, Jennifer L.
丘脑底核(STH)被认为是参与药物奖赏动机的重要区域。目前尚不清楚主要负责奖赏信号的神经递质多巴胺是否也参与调节Sib中与奖赏相关的活动。神经肽催产素通过与多巴胺的相互作用，在STH内起作用，以减少精神刺激剂甲基苯丙胺的奖赏效应。然而，这种相互作用的机制尚不清楚。本研究旨在确定(I)多巴胺微量注射到SSH是否会在单次条件反射后导致显著的位置偏爱，(Ii)共用多巴胺受体拮抗剂是否会阻止对多巴胺的条件性位置偏爱(CPP)的形成，(Iii)共用催产素是否会阻止对多巴胺的条件性位置偏爱(CPP)，以及(Iv)选择性催产素拮抗剂desGly-NH2，d(CH2)(5)[D-Tyr(2)，Thr(4)]OVT与催产素和多巴胺联合应用是否会逆转催产素的作用并导致多巴胺的条件性位置偏爱。结果显示，雄性SD大鼠(1)对多巴胺(100 nmol/侧)给药形成偏爱，这种偏爱可被2)混合多巴胺受体拮抗剂氟奋乃静(10 nmol/侧)或3)催产素(0.6 nmol/侧)联合给药所阻止，催产素对多巴胺CPP的作用可被催产素受体拮抗剂(3 nmol/侧)所逆转。这些数据表明，STH中的多巴胺神经传递产生了奖励效应，这种效应可以通过激活局部催产素受体来减少。(C)2013 Elsevier Inc.保留所有权利。
The subthalamic nucleus (STh) is increasingly recognized as an important region involved in the motivation for drug reward. It is not yet known if dopamine, the neurotransmitter primarily responsible for reward signaling, is also involved in mediating reward-related activity in the Sib. The neuropeptide oxytocin acts within the STh to reduce the rewarding effects of the psychostimulant methamphetamine, through a proposed interaction with dopamine. However, the mechanisms of this interaction are unclear. The current study aimed to determine whether (i) dopamine microinjected into the STh would result in a significant place preference following a single-trial conditioning session, (ii) co-administered dopamine receptor antagonist would block the formation of a conditioned place preference (CPP) for dopamine, (iii) co-administered oxytocin would prevent CPP for dopamine and (iv) whether the selective oxytocin antagonist desGly-NH2,d(CH2)(5)[D-Tyr(2),Thr(4)]OVT, when co-administered with oxytocin and dopamine, would reverse the effects of oxytocin and result in a CPP for dopamine. Results showed that male Sprague Dawley rats i) formed a preference for the context paired with dopamine (100 nmol/side) administration into the STh, which was prevented by co-administration of ii) the mixed dopamine receptor antagonist fluphenazine (10 nmol/side) or iii) oxytocin (0.6 nmol/side), with the oxytocin effect on dopamine CPP reversed by the co-administration of the oxytocin receptor antagonist (3 nmol/side). These data suggest that dopamine neurotransmission in the STh produces rewarding effects that can be reduced by activation of local oxytocin receptors. (C) 2013 Elsevier Inc. All rights reserved.