Mouse duplicate genes are as essential as singletons
Mouse duplicate genes are as essential as singletons
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DOI：
10.1016/j.tig.2007.05.006
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发表时间：
2007-08-01
影响因子：
11.4
通讯作者：
Zhang, Jianzhi
中科院分区：
文献类型：
--
作者：
Liao, Ben-Yang;Zhang, Jianzhi
小鼠中的重复基因被广泛认为具有功能冗余性，并且不如单拷贝基因那么重要。我们分析了近3900个单独敲除的小鼠基因，发现单拷贝基因和重复基因中必需基因的比例都接近55%。这表明哺乳动物的重复基因很少相互补偿，并且在缺失一个重复基因的小鼠中没有表型不应自动归因于旁系同源基因的补偿。
Duplicate genes in mouse are widely thought to have functional redundancy, and to be less essential than singleton genes. We analyzed nearly 3900 individually knocked out mouse genes and discovered that the proportion of essential genes is similar to 55% in both singletons and duplicates. This suggests that mammalian duplicates rarely compensate for each other, and that the absence of phenotypes in mice deficient for a duplicate gene should not be automatically attributed to paralogous compensation.