Oral treatment with complement factor C5a receptor (CD88) antagonists inhibits experimental periodontitis in rats
Oral treatment with complement factor C5a receptor (CD88) antagonists inhibits experimental periodontitis in rats
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DOI：
10.1111/j.1600-0765.2011.01383.x
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发表时间：
2011-12-01
影响因子：
3.5
通讯作者：
Opstad, P. K.
中科院分区：
文献类型：
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作者：
Breivik, T.;Gundersen, Y.;Opstad, P. K.
背景与目的：补体激活产物5a（C5a）是感染固有免疫应答的一种强效介质，因此可能对牙周炎的发展也起重要作用。本研究旨在在动物模型中探究几种新型、强效且口服有效的C5a受体（CD88）拮抗剂（C5aRAs）对结扎诱导的牙周炎发展的影响。
材料与方法：研究了三种不同的环肽C5aRAs，分别称为PMX205、PMX218和PMX273。使用四组Wistar大鼠（每组n = 10）。在诱导实验性牙周炎前3天开始，大鼠要么在饮用水中接受一种C5aRA（1 - 2mg/kg），要么仅饮用普通水。在结扎14天后评估牙周炎情况。
结果：与对照组大鼠相比，PMX205和PMX218处理的大鼠牙周骨丧失显著减少。
结论：研究结果表明补体激活，尤其是C5a的产生，可能在牙周炎的发生和发展中起重要作用。用诸如PMX205等特异性抑制剂阻断主要的C5a受体CD88，可能为牙周炎提供新的治疗选择。
Background and Objective: The complement activation product 5a (C5a) is a potent mediator of the innate immune response to infection, and may thus also importantly determine the development of periodontitis. The present study was designed to explore the effect of several novel, potent and orally active C5a receptor (CD88) antagonists (C5aRAs) on the development of ligature-induced periodontitis in an animal model.Material and Methods: Three different cyclic peptide C5aRAs, termed PMX205, PMX218 and PMX273, were investigated. Four groups of Wistar rats (n = 10 in each group) were used. Starting 3 d before induction of experimental periodontitis, rats either received one of the C5aRas (1-2 mg/kg) in the drinking water or received drinking water only. Periodontitis was assessed when the ligatures had been in place for 14 d.Results: Compared with control rats, PMX205- and PMX218-treated rats had significantly reduced periodontal bone loss.Conclusion: The findings suggest that complement activation, and particularly C5a generation, may play a significant role in the development and progression of periodontitis. Blockade of the major C5a receptor, CD88, with specific inhibitors such as PMX205, may offer novel treatment options for periodontitis.