Values of serum CA125, NSE and 24-hour urine VMA in diagnosis and prediction of treatment of paediatric neuroblastoma
Values of serum CA125, NSE and 24-hour urine VMA in diagnosis and prediction of treatment of paediatric neuroblastoma
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DOI：
10.1111/ijcp.14932
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发表时间：
2021-10-15
影响因子：
2.6
通讯作者：
Wang, Xinning
中科院分区：
文献类型：
--
作者：
Li, Jinmin;Liu, Xiangyang;Wang, Xinning
背景儿童神经母细胞瘤是一种比较常见的起源于神经脊组织的恶性肿瘤。早期诊断和采取针对性的治疗策略可以提高儿童神经母细胞瘤的存活率和改善预后。方法选择86例神经母细胞瘤患儿为研究对象，50例1~12岁健康儿童为对照组。用高效液相色谱法测定24小时尿香草扁桃酸(VMA)。用Cobas E411全自动生化分析仪测定血清糖类抗原125、CA125和神经元特异性烯醇化酶(NSE)水平。结果Ⅲ-IVs期神经母细胞瘤患儿血清CA125、NSE、24小时尿VMA水平明显高于临床I-II期患儿，治疗有效组患儿血清CA125、NSE、24小时尿VMA水平显著低于治疗无效组。血清CA125的灵敏度为71.88%，特异度为59.26%，曲线下面积为0.7049。血清NSE的敏感性和特异性分别为68.75%和81.48%，AUC值为0.7407。24小时尿VMA的敏感性和特异性分别为90.63%和59.26%，结合AUC值为0.7986。结论治疗前血清CA125、NSE和24小时尿VMA水平可作为神经母细胞瘤患儿病情评估和疗效预测的指标。
Background Paediatric neuroblastoma is a relatively common type of malignant tumour originating from neural crest tissues. Early diagnosis and the performance of specific therapeutic strategies can increase the survival rate and improve the prognosis of children with neuroblastoma. Methods A total of 86 children with neuroblastoma were recruited in this research, and 50 healthy children aged 1-12 years were also selected as controls. Twenty-four-hour urine vanillylmandelic acid (VMA) was evaluated by high-performance liquid chromatography. Serum carbohydrate antigen 125 CA125 and neuron-specific enolase (NSE) levels were evaluated by electrochemiluminescence in Cobas E411 autoanalyser. Results The serum CA125, NSE and 24-hour urine VMA levels of children with stage III-IVs neuroblastoma were significantly higher than those of children with clinical stages I-II; the serum CA125, NSE and 24-hour urine VMA levels of children in the effective treatment group were significantly lower than those in the treatment-ineffective group. The serum CA125 generated sensitivity and specificity of 71.88% and 59.26%, combined with an AUC (area under the curve) of 0.7049. The serum NSE generated sensitivity and specificity of 68.75% and 81.48%, combined with an AUC of 0.7407. The 24-hour urine VMA generated sensitivity and specificity of 90.63% and 59.26%, combined with an AUC of 0.7986. Conclusion In conclusion, serum CA125, NSE and 24-hour urine VMA levels before treatment could assess the condition of children with neuroblastoma and predict the effect of treatment.