THE PREDISPOSING AND PROTECTIVE FACTORS AGAINST DENGUE VIRUS TRANSMISSION BY MOSQUITO VECTOR
THE PREDISPOSING AND PROTECTIVE FACTORS AGAINST DENGUE VIRUS TRANSMISSION BY MOSQUITO VECTOR
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DOI：
10.1093/oxfordjournals.aje.a116487
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发表时间：
1992-07-15
影响因子：
5
通讯作者：
YEH, SM
中科院分区：
文献类型：
--
作者：
KO, YC;CHEN, MJ;YEH, SM
台湾于1987年至1988年间爆发登革热。高雄市的成人感染率最高，估计为5.6%。开展了一项病例对照研究，以确定感染登革热的风险，并确定防止感染的保护因素。通过病毒学或血清学检测诊断的100例作者所在医院的登革热患者构成病例组。每名登革热患者与一名与该登革热患者同一天被诊断患有非媒介传播疾病的年龄和性别相同的对照患者相匹配。通过分层分析估计，在发病前对登革热感染采取家庭防护措施的人群中，与未进行筛查的人群相比，居住在筛查房屋中的人群调整后的优势比更低（优势比= 0.58,95%可信区间0.36-0.92）。比值比低至0。18（95%可信区间为0.06-0.56）的人的家庭是完全屏蔽的，门帘向外打开。居住在市场和/或露天下水道或沟渠附近的患者感染登革热的风险比居住在其他地方的患者高1.8倍（95%置信区间为1.3-2.4）。为了控制登革热暴发，作者建议应特别注意减少室外媒介来源。全面筛查，特别是向外打开纱门，似乎是个人预防登革热的最佳保护措施。
An outbreak of dengue fever-occurred in Taiwan between 1987 and 1988. The highest attack rate among adults was estimated at 5.6% in the city of Kao-hsiung. A case-control study was carried out to determine the risks of contracting dengue infection and to identify protective factors against the infection. One hundred dengue patients of the authors' hospital who were diagnosed by virologic or serologic tests constituted the case group. Each dengue patient was matched to a control patient of the same age and sex who had been diagnosed as suffering from a non-vector-borne disease on the same day as the dengue patient. Of the household protective measures against dengue infection prior to the occurrence of illness, the adjusted odds ratio, estimated by stratified analysis, was lower for people who lived in screened houses (odds ratio = 0.58, 95% confidence interval 0.36-0.92) as compared with inhabitants of unscreened houses. The odds ratio was as low as 0. 1 8 (95% confidence interval 0.06-0.56) for people whose homes were fully screened with door screens opening outwardly. Patients who lived near markets and/or open sewers or ditches were running a risk of dengue infection 1.8 (95% confidence interval 1.3-2.4) times higher than those who lived elsewhere. To control dengue outbreaks, the authors recommend that special attention should be devoted to the reduction of outdoor vector sources. Full screening, especially outwardly opening screen doors, seems to be an individual's best protection against dengue fever.