Intraoperative Fluorescence Imaging for Personalized Brain Tumor Resection: Current State and Future Directions.
Intraoperative Fluorescence Imaging for Personalized Brain Tumor Resection: Current State and Future Directions.
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DOI：
10.3389/fsurg.2016.00055
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发表时间：
2016
影响因子：
1.8
通讯作者：
Preul MC
中科院分区：
文献类型：
--
作者：
Belykh E;Martirosyan NL;Yagmurlu K;Miller EJ;Eschbacher JM;Izadyyazdanabadi M;Bardonova LA;Byvaltsev VA;Nakaji P;Preul MC
放射性引导手术是外科“治疗诊断学”中迅速兴起的方法之一。在这篇综述中，我们总结了目前的荧光技术用于脑肿瘤患者的神经外科实践，以及未来的应用，最近的实验室和转化研究。文献综述。广泛的荧光团，已被测试的脑外科手术进行审查。从1948年摩尔应用荧光素钠开始，荧光引导的脑肿瘤手术要么在一些中心常规应用，要么在临床试验中积极研究。除了Trinity的常用药物（荧光素钠、5-氨基乙酰丙酸和吲哚菁绿色）之外，研究较少的荧光染料，如四环素、癌症选择性烷基磷酸胆碱类似物、甲酚紫、吖啶橙子和吖啶黄，可用于快速肿瘤检测和病理组织检查。其他新兴的代理商，如活性为基础的探针和有针对性的分子探针，可以提供生物分子特异性的手术可视化和治疗，进行审查。此外，我们回顾了荧光手术可视化的工程和光学解决方案。用于荧光引导手术的仪器分为宽视野成像系统和手持式探头。最新进展，定量荧光引导手术进行了讨论。我们正站在标志物辅助肿瘤管理时代的门槛上。手术光学、计算机图像分析和分子生物工程领域的创新正在推进荧光引导的肿瘤切除范例，从而导致脑肿瘤可视化和切除的细胞水平方法。
Fluorescence-guided surgery is one of the rapidly emerging methods of surgical “theranostics.” In this review, we summarize current fluorescence techniques used in neurosurgical practice for brain tumor patients as well as future applications of recent laboratory and translational studies. Review of the literature. A wide spectrum of fluorophores that have been tested for brain surgery is reviewed. Beginning with a fluorescein sodium application in 1948 by Moore, fluorescence-guided brain tumor surgery is either routinely applied in some centers or is under active study in clinical trials. Besides the trinity of commonly used drugs (fluorescein sodium, 5-aminolevulinic acid, and indocyanine green), less studied fluorescent stains, such as tetracyclines, cancer-selective alkylphosphocholine analogs, cresyl violet, acridine orange, and acriflavine, can be used for rapid tumor detection and pathological tissue examination. Other emerging agents, such as activity-based probes and targeted molecular probes that can provide biomolecular specificity for surgical visualization and treatment, are reviewed. Furthermore, we review available engineering and optical solutions for fluorescent surgical visualization. Instruments for fluorescent-guided surgery are divided into wide-field imaging systems and hand-held probes. Recent advancements in quantitative fluorescence-guided surgery are discussed. We are standing on the threshold of the era of marker-assisted tumor management. Innovations in the fields of surgical optics, computer image analysis, and molecular bioengineering are advancing fluorescence-guided tumor resection paradigms, leading to cell-level approaches to visualization and resection of brain tumors.
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影响因子：
3.7
作者：
Chi C;Ye J;Ding H;He D;Huang W;Zhang GJ;Tian J
通讯作者：
Tian J
影响因子：
3.6
作者：
Chen B;Wang H;Ge P;Zhao J;Li W;Gu H;Wang G;Luo Y;Chen D
通讯作者：
Chen D
影响因子：
14.8
作者：
Blum, Galia;von Degenfeld, Georges;Bogyo, Matthew
通讯作者：
Bogyo, Matthew
使用靶向近红外荧光探针进行成像引导手术术中识别肝癌微病灶
影响因子：
4.6
作者：
Chi C;Zhang Q;Mao Y;Kou D;Qiu J;Ye J;Wang J;Wang Z;Du Y;Tian J
通讯作者：
Tian J
影响因子：
7.3
作者：
Akcan M;Stroud MR;Hansen SJ;Clark RJ;Daly NL;Craik DJ;Olson JM
通讯作者：
Olson JM