T follicular helper cells in cancer, tertiary lymphoid structures, and beyond.
T follicular helper cells in cancer, tertiary lymphoid structures, and beyond.
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DOI：
10.1016/j.smim.2023.101797
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发表时间：
2023-06
影响因子：
7.8
通讯作者：
Can Cui;J. Craft;Nikhil S. Joshi
中科院分区：
文献类型：
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作者：
Can Cui;J. Craft;Nikhil S. Joshi
随着检查点阻断免疫疗法的出现和成功，免疫肿瘤学主要关注 CD8 T 细胞，其细胞毒性程序直接针对肿瘤细胞。然而，当前免疫治疗方案的有限反应率促使人们研究其他类型的肿瘤浸润免疫细胞，例如 CD4 T 细胞和 B 细胞，以及它们如何在协调网络中与 CD8 T 细胞相互作用。最近的研究证明了 CD4 T 滤泡辅助细胞 (TFH) 和 B 细胞在癌症中的潜在治疗益处，强调了它们与肿瘤微环境中其他免疫细胞成分的串扰和相互作用的重要作用。这些相互作用也发生在肿瘤相关的三级淋巴结构（TLS）中，其类似于二级淋巴器官（SLO），具有精心设计的血管、趋化因子和细胞基础设施，支持功能性免疫细胞的发育途径。在这篇综述中，我们讨论了肿瘤免疫学中 TFH 生物学和 T 细胞-B 细胞相互作用的最新突破，以及它们作为推进癌症治疗的新治疗靶点的潜力。
With the emergence and success of checkpoint blockade immunotherapy, immuno-oncology has primarily focused on CD8 T cells, whose cytotoxic programs directly target tumor cells. However, the limited response rate of current immunotherapy regimens has prompted investigation into other types of tumor-infiltrating immune cells, such as CD4 T cells and B cells, and how they interact with CD8 T cells in a coordinated network. Recent studies have demonstrated the potential therapeutic benefits of CD4 T follicular helper (TFH) cells and B cells in cancer, highlighting the important role of their crosstalk and interactions with other immune cell components in the tumor microenvironment. These interactions also occur in tumor-associated tertiary lymphoid structures (TLS), which resemble secondary lymphoid organs (SLOs) with orchestrated vascular, chemokine, and cellular infrastructures that support the developmental pathways of functional immune cells. In this review, we discuss recent breakthroughs on TFH biology and T cell-B cell interactions in tumor immunology, and their potential as novel therapeutic targets to advance cancer treatment.