Short chain fatty acid distributions of enema samples from a sigmoidoscopy population: an association of high acetate and low butyrate ratios with adenomatous polyps and colon cancer.
Short chain fatty acid distributions of enema samples from a sigmoidoscopy population: an association of high acetate and low butyrate ratios with adenomatous polyps and colon cancer.
复制标题
乙状结肠镜检查人群灌肠样本的短链脂肪酸分布：高乙酸盐和低丁酸盐比率与腺瘤性息肉和结肠癌的关联。
作者：
Weaver,GA;Krause,JA;Miller,TL;Wolin,MJ
我们研究了乙状结肠镜检查前受试者灌肠样本中短链脂肪酸（SCFA）的分布，作为随后诊断为正常或结肠疾病的受试者之间可能的微生物群落差异的指标。所有组中的主要SCFA为乙酸、丙酸和丁酸。与正常人相比，结肠息肉癌受试者的乙酸盐与总SCFA的比率显著较高，丁酸盐与总SCFA的比率较低。憩室病组或炎症组与正常组之间乙酸、丙酸或丁酸的比值无显著差异。有没有显着的性别差异，也没有相关性的比率乙酸，丙酸或丁酸和年龄，受试者体重，或干重的样品。个别酸的浓度显着差异，发现正常和某些诊断组之间。各组之间个体SCFA比例的差异表明结肠微生物区系的发酵模式存在差异。
We investigated the distribution of short chain fatty acids (SCFA) in enema samples taken from subjects before sigmoidoscopy as an indicator of possible microbial community differences between subjects subsequently diagnosed as normal or having colonic disorders. The major SCFA in all groups were acetic, propionic, and butyric acids. A significantly higher ratio of acetate to total SCFA and lower ratio of butyrate to total SCFA was found for polyp-colon cancer subjects than for normal subjects. There were no significant differences in the ratios of acetate, propionate, or butyrate between the diverticulosis or inflammatory bowel groups and the normal group. There were no significant sex differences nor were there correlations with the ratios of acetate, propionate or butyrate and age, subject weight, or dry weights of samples. Significant differences in concentrations of individual acids were found between normal and certain diagnostic groups. The difference in proportions of individual SCFA between groups suggest differences in fermentation patterns of the colonic microflora.