Planning clinical trials to evaluate early detection programmes
Planning clinical trials to evaluate early detection programmes
复制标题
规划临床试验以评估早期检测计划
DOI：
10.1093/biomet/84.4.817
复制
发表时间：
1997
期刊：
影响因子：
2.7
通讯作者：
M. Zelen
中科院分区：
文献类型：
--
作者：
P. Hu;M. Zelen
SUMMARY The lack of statistical theory for the planning of early detection trials has resulted in current trials being sub-optimal. We develop probability models that address three characteristics of early detection trials: (i) the optimal time of analysis and length of follow-up, (ii) the optimal spacing between examinations, and (iii) the planning of trials where the numbers of examinations versus sample size are balanced for fixed costs. The optimisation criterion is to maximise the power of the statistical test for comparing mortality. Application is made to breast cancer early detection trials.
