Cerebellar Dentate Connectivity across Adulthood: A Large-Scale Resting State Functional Connectivity Investigation.
Cerebellar Dentate Connectivity across Adulthood: A Large-Scale Resting State Functional Connectivity Investigation.
复制标题
小脑齿状连通性在整个成年期：一项大规模的静止状态功能连接研究。
DOI：
10.1093/texcom/tgab050
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发表时间：
2021
影响因子：
--
通讯作者：
Jackson TB
中科院分区：
文献类型：
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作者：
Bernard JA;Ballard HK;Jackson TB
考虑到小脑在运动和认知表现中的作用，小脑对老年人行为的贡献是令人感兴趣和重要的。老年人小脑结构存在差异和衰退，小脑静息态连接性降低。然而，到目前为止，这方面的工作主要集中在小脑皮层。小脑深核为皮质、脊髓和前庭系统提供主要的小脑输入和输出。齿状网络可以被分离，使得背侧区域与运动皮层相关联，而腹侧方面与前额叶皮层相关联。然而，成年期的齿状核-丘脑-皮质网络是否不同仍然未知。在这里，我们使用来自剑桥老龄化和神经科学中心的大型成人样本（n = 590），研究了成年期的齿状连接。我们复制了过去的工作，显示在齿状回的背侧和腹侧的可分离的静息态网络。在这两个种子中，我们证明了连接性随着年龄的增长而降低，这表明连接性差异超出了小脑皮层。最后，我们证明了齿状连接的性别差异。这扩展了我们对老年小脑回路的理解，并强调了这种结构在与年龄相关的性能差异中的潜在重要性。
Cerebellar contributions to behavior in advanced age are of interest and importance, given its role in motor and cognitive performance. There are differences and declines in cerebellar structure in advanced age and cerebellar resting state connectivity is lower. However, the work on this area to date has focused on the cerebellar cortex. The deep cerebellar nuclei provide the primary cerebellar inputs and outputs to the cortex, as well as the spinal and vestibular systems. Dentate networks can be dissociated such that the dorsal region is associated with the motor cortex, whereas the ventral aspect is associated with the prefrontal cortex. However, whether dentato-thalamo-cortical networks differ across adulthood remains unknown. Here, using a large adult sample (n = 590) from the Cambridge Center for Ageing and Neuroscience, we investigated dentate connectivity across adulthood. We replicated past work showing dissociable resting state networks in the dorsal and ventral aspects of the dentate. In both seeds, we demonstrated that connectivity is lower with advanced age, indicating that connectivity differences extend beyond the cerebellar cortex. Finally, we demonstrated sex differences in dentate connectivity. This expands our understanding of cerebellar circuitry in advanced age and underscores the potential importance of this structure in age-related performance differences.