Nuclear Fibroblast Growth Factor Receptor Signaling in Skeletal Development and Disease.
Nuclear Fibroblast Growth Factor Receptor Signaling in Skeletal Development and Disease.
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DOI：
10.1007/s11914-019-00512-2
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发表时间：
2019-06
影响因子：
4.3
通讯作者：
Merrill AE
中科院分区：
文献类型：
--
作者：
Tuzon CT;Rigueur D;Merrill AE
Fibroblast growth factor receptor (FGFR) signaling regulates proliferation and differentiation during development and homeostasis. While membrane-bound FGFRs play a central role in these processes, the function of nuclear FGFRs is also critical. Here, we highlight mechanisms for nuclear FGFR translocation and the effects of nuclear FGFRs on skeletal development and disease. Full-length FGFRs, internalized by endocytosis, enter the nucleus through β-importin-dependent mechanisms that recognize the nuclear localization signal within FGFs. Alternatively, soluble FGFR intracellular fragments undergo nuclear translocation following their proteolytic release from the membrane. FGFRs enter the nucleus during the cellular transition between proliferation and differentiation. Once nuclear, FGFRs interact with chromatin remodelers to alter the epigenetic state and transcription of their target genes. Dysregulation of nuclear FGFR is linked to the etiology of congenital skeletal disorders and neoplastic transformation. Revealing the activities of nuclear FGFR will advance our understanding of 20 congenital skeletal disorders caused by FGFR mutations, as well as FGFR-related cancers.
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DOI：
10.1073/pnas.0502041102
发表时间：
2005-07-12
影响因子：
11.1
作者：
Feng, DX;Kan, YW
通讯作者：
Kan, YW
DOI：
10.1073/pnas.0702581104
发表时间：
2007-10-16
影响因子：
11.1
作者：
Kim, Yuna;Bingham, Nathan;Capel, Blanche
通讯作者：
Capel, Blanche
影响因子：
3.8
作者：
Cerliani, Juan P.;Vanzulli, Silvia I.;Lamb, Caroline A.
通讯作者：
Lamb, Caroline A.
DOI：
10.1083/jcb.201108077
发表时间：
2012-06-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
Chioni AM;Grose R
通讯作者：
Grose R
影响因子：
11.1
作者：
Coleman, Stacey J.;Chioni, Athina-Myrto;Ghallab, Mohammed;Anderson, Rhys K.;Lemoine, Nicholas R.;Kocher, Hemant M.;Grose, Richard P.
通讯作者：
Grose, Richard P.