Genetic heterogeneity of hepatitis E virus in Darfur, Sudan, and neighboring Chad
Genetic heterogeneity of hepatitis E virus in Darfur, Sudan, and neighboring Chad
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DOI：
10.1002/jmv.20487
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发表时间：
2005-12-01
影响因子：
12.7
通讯作者：
Andraghetti, R
中科院分区：
文献类型：
--
作者：
Nicand, E;Armstrong, GL;Andraghetti, R
2004年苏丹发生戊型肝炎疫情期间，研究了戊型肝炎病毒（HEV）疫情内的多样性。从生活在苏丹难民营和乍得两个难民营的境内流离失所者身上采集了标本。23个苏丹分离株和来自乍得两个营地的5个HEV样品的ORF2区域的序列比较显示出与属于基因型1的菌株的高度相似性（> 99.7%）。但是在乍得的一个营地收集的四个分离株接近基因型2。不同菌株的传播证明可能存在多种感染源。
The within-outbreak diversity of hepatitis E virus (HEV) was studied during the outbreak of hepatitis E that occurred in Sudan in 2004. Specimens were collected from internally displaced persons living in a Sudanese refugee camp and two camps implanted in Chad. A comparison of the sequences in the ORF2 region of 23 Sudanese isolates and five HEV samples from the two Chadian camps displayed a high similarity (> 99.7%) to strains belonging to Genotype 1. But four isolates collected in one of the Chadian camps were close to Genotype 2. Circulation of divergent strains argues for possible multiple sources of infection.