RECURRENT REARRANGEMENTS OF 11Q14-22 IN MUCOEPIDERMOID CARCINOMA
RECURRENT REARRANGEMENTS OF 11Q14-22 IN MUCOEPIDERMOID CARCINOMA
复制标题
DOI：
10.1016/0165-4608(94)90001-9
复制
发表时间：
1994-06-01
影响因子：
--
通讯作者：
STENMAN, G
中科院分区：
文献类型：
--
作者：
NORDKVIST, A;GUSTAFSSON, H;STENMAN, G
我们描述的细胞遗传学研究结果在五个粘液表皮样癌（MEC）的大小唾液腺。分析的5个肿瘤中有3个显示出明显相同的t（11;19）（q14-21;p12）。其中1例为t（11;19），另2例分别为+16、+20、inv（1）（p32- 33 q42）、t（6;15）（p12;q25）易位。后一个病例还显示der（11）染色体的间质短臂缺失。在剩下的两个病例中，一个具有del（3）（p13 p23）作为唯一的核型异常，而另一个具有超二倍体干细胞系，其特征在于以下数值偏差：+2、+5、+6、+7、+8、+17、+18和+19。这些发现，加上先前发表的7例MEC的数据，表明至少存在两种不同的、部分重叠的细胞遗传学亚群：1）11 q14 -22结构重排的病例; 3例肿瘤具有明显相同的t（11;19）（q14-21;p12）表明这是MEC中的非随机的并且可能是原发性异常，以及2）单个或多个三体，作为唯一异常或与结构重排组合观察到。
We describe the cytogenetic findings in five mucoepidermoid carcinomas (MEC) of the major and minor salivary glands. Three of the five tumors analyzed showed an apparently identical t(11;19)(q14-21;p12). In one case, the t(11;19) was the only common clonal abnormality, while in the other two cases the translocation was found together with +16, +20, and inv(1)(p32-33q42), t(6;15)(p12;q25), respectively. The latter case also showed an interstitial short arm deletion of the der(11) chromosome. Of the two remaining cases, one had a del(3)(p13p23) as the sole karyotypic abnormality, while the other had a hyperdiploid stemline characterized by the following numerical deviations: +2, +5, +6, +7, +8, +17, +18, and +19. These findings, together with previously published data from seven MEC, indicate that at least two different, partially overlapping cytogenetic subgroups exist: 1) cases with structural rearrangements of 11q14-22; the finding of three tumors with an apparently identical t(11;19)(q14-21;p12) demonstrates that this is a non-random, and possibly primary abnormality in MEC, and 2) single or multiple trisomies, either observed as the sole anomalies or in combination with structural rearrangements.