Increased exercise level and plasma lipoprotein concentrations: a one-year, randomized, controlled study in sedentary, middle-aged men.
Increased exercise level and plasma lipoprotein concentrations: a one-year, randomized, controlled study in sedentary, middle-aged men.
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增加运动水平和血浆脂蛋白浓度：一项针对久坐的中年男性的为期一年的随机对照研究。
DOI：
10.1016/0026-0495(83)90152-x
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Farquhar,JW
中科院分区：
文献类型：
--
作者：
Wood,PD;Haskell,WL;Blair,SN;Williams,PT;Krauss,RM;Lindgren,FT;Albers,JJ;Ho,PH;Farquhar,JW
81名30-55岁的久坐但健康的男性参加了一项为期1年的运动对血浆脂蛋白浓度影响的随机研究。48人被分配到跑步项目，而33人仍然是久坐不动的对照组（比例约为3：2）。一年后，跑步组比对照组明显更健康、更苗条。跑步者（与对照组相比）的脂蛋白浓度变化一致有利于降低冠心病的风险，但当所有46名具有完整数据的参与者都被纳入时，这些变化并不显著。然而，与对照组相比，25名平均每周跑步至少8英里（12.9公里）的男性的血浆高密度脂蛋白（HDL）胆固醇水平增加了4.4 mg/dl（p= 0.045），HDL 2质量水平增加了33 mg/dl（p= 0.059）。发现每周跑的距离与血浆HDL-胆固醇（r= 0.48）、HDL 2（r= 0.41）和低密度脂蛋白胆固醇（r=-0.31）的变化存在显著相关性。在跑步者中，体脂百分比和HDL-胆固醇的变化是相关的（r=-0.47）。似乎存在一个阈值，即每周8英里，超过这个阈值，1年的跑步计划会导致有益的脂蛋白变化。
Eighty-one sedentary but healthy men aged 30–55 participated in a 1 yr randomized study of the effects of exercise on plasma lipoprotein concentrations. Forty-eight were assigned to a running program, while 33 remained as sedentary controls (an approximately 3:2 ratio). After 1 yr the running group had become significantly fitter and leaner than the control group. Lipoprotein concentration changes in the runners (vs. controls) uniformly favored reduced risk of coronary heart disease, but were not significant when all 46 participants with complete data were included. However, the 25 men who averaged at least eight miles (12.9 kilometers) per wk of running increased their plasma high-density-lipoprotein (HDL) cholesterol level by 4.4 mg/dl (p= 0.045) and their HDL2mass level by 33 mg/dl (p= 0.059), vs. controls. Significant correlations were found for distance run per wk vs. change in plasma HDL-cholesterol (r= 0.48), HDL2(r= 0.41), and low-density-lipoprotein cholesterol (r= −0.31). Changes in percent body fat and in HDL-cholesterol were correlated (r= −0.47) in runners. There appears to be a threshold at about 8 miles per wk above which a 1-yr running program leads to beneficial lipoprotein changes.